LRRC75B protein (human) - STRING interaction network

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LRRC75B

Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B. (315 aa)

Predicted Functional Partners:

GUCD1

0.731

GSTT4

0.696

UPB1

0.531

SPECC1L

0.498

C22orf15

0.496

AFG1L

0.488

DRICH1

0.475

DDX39A

0.457

GAGE12J

0.451

CABIN1

0.448

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFG1L	DDX39A	ENSP00000357973	ENSP00000242776	AFG1-like ATPase; Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.	ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily.	0.463
AFG1L	GSTT4	ENSP00000357973	ENSP00000492273	AFG1-like ATPase; Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.	Glutathione S-transferase theta-4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Theta family.	0.449
AFG1L	GUCD1	ENSP00000357973	ENSP00000479370	AFG1-like ATPase; Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.	Protein GUCD1; Guanylyl cyclase domain containing 1.	0.446
AFG1L	LRRC75B	ENSP00000357973	ENSP00000320520	AFG1-like ATPase; Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.	Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B.	0.488
C22orf15	DRICH1	ENSP00000305096	ENSP00000316137	Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15.	Aspartate-rich protein 1; Aspartate rich 1.	0.450
C22orf15	LRRC75B	ENSP00000305096	ENSP00000320520	Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15.	Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B.	0.496
CABIN1	GUCD1	ENSP00000381364	ENSP00000479370	Calcineurin-binding protein cabin-1; May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.	Protein GUCD1; Guanylyl cyclase domain containing 1.	0.414
CABIN1	LRRC75B	ENSP00000381364	ENSP00000320520	Calcineurin-binding protein cabin-1; May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.	Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B.	0.448
DDX39A	AFG1L	ENSP00000242776	ENSP00000357973	ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily.	AFG1-like ATPase; Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.	0.463
DDX39A	LRRC75B	ENSP00000242776	ENSP00000320520	ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily.	Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B.	0.457
DRICH1	C22orf15	ENSP00000316137	ENSP00000305096	Aspartate-rich protein 1; Aspartate rich 1.	Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15.	0.450
DRICH1	LRRC75B	ENSP00000316137	ENSP00000320520	Aspartate-rich protein 1; Aspartate rich 1.	Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B.	0.475
GAGE12J	LRRC75B	ENSP00000409832	ENSP00000320520	G antigen 12J.	Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B.	0.451
GSTT4	AFG1L	ENSP00000492273	ENSP00000357973	Glutathione S-transferase theta-4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Theta family.	AFG1-like ATPase; Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.	0.449
GSTT4	GUCD1	ENSP00000492273	ENSP00000479370	Glutathione S-transferase theta-4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Theta family.	Protein GUCD1; Guanylyl cyclase domain containing 1.	0.595
GSTT4	LRRC75B	ENSP00000492273	ENSP00000320520	Glutathione S-transferase theta-4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Theta family.	Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B.	0.696
GSTT4	SPECC1L	ENSP00000492273	ENSP00000325785	Glutathione S-transferase theta-4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Theta family.	Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.	0.416
GSTT4	UPB1	ENSP00000492273	ENSP00000324343	Glutathione S-transferase theta-4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Theta family.	Beta-ureidopropionase; Catalyzes a late step in pyrimidine degradation. Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide. Likewise, converts N-carbamoyl-beta- aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide (Probable). Belongs to the carbon-nitrogen hydrolase superfamily. BUP family.	0.532
GUCD1	AFG1L	ENSP00000479370	ENSP00000357973	Protein GUCD1; Guanylyl cyclase domain containing 1.	AFG1-like ATPase; Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.	0.446
GUCD1	CABIN1	ENSP00000479370	ENSP00000381364	Protein GUCD1; Guanylyl cyclase domain containing 1.	Calcineurin-binding protein cabin-1; May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.	0.414