| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LUC7L | LUC7L2 | ENSP00000293872 | ENSP00000347005 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | 0.999 |
| LUC7L | LUC7L3 | ENSP00000293872 | ENSP00000376919 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | 0.983 |
| LUC7L | PNISR | ENSP00000293872 | ENSP00000496842 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | 0.424 |
| LUC7L | PRPF39 | ENSP00000293872 | ENSP00000348010 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing. | 0.979 |
| LUC7L | RBM25 | ENSP00000293872 | ENSP00000261973 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7 [...] | 0.933 |
| LUC7L | SF3B1 | ENSP00000293872 | ENSP00000335321 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). May also be involved [...] | 0.969 |
| LUC7L | SNRNP70 | ENSP00000293872 | ENSP00000472998 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. | 0.997 |
| LUC7L | SNRPD2 | ENSP00000293872 | ENSP00000342374 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. | 0.994 |
| LUC7L | SRPK2 | ENSP00000293872 | ENSP00000377262 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | SRSF protein kinase 2 C-terminal; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates [...] | 0.997 |
| LUC7L | U2AF2 | ENSP00000293872 | ENSP00000307863 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Splicing factor U2AF 65 kDa subunit; Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucl [...] | 0.987 |
| LUC7L2 | LUC7L | ENSP00000347005 | ENSP00000293872 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | 0.999 |
| LUC7L2 | LUC7L3 | ENSP00000347005 | ENSP00000376919 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | 0.998 |
| LUC7L2 | PNISR | ENSP00000347005 | ENSP00000496842 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | 0.475 |
| LUC7L2 | PRPF39 | ENSP00000347005 | ENSP00000348010 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing. | 0.970 |
| LUC7L2 | RBM25 | ENSP00000347005 | ENSP00000261973 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7 [...] | 0.814 |
| LUC7L2 | SF3B1 | ENSP00000347005 | ENSP00000335321 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). May also be involved [...] | 0.974 |
| LUC7L2 | SNRNP70 | ENSP00000347005 | ENSP00000472998 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. | 0.997 |
| LUC7L2 | SNRPD2 | ENSP00000347005 | ENSP00000342374 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. | 0.997 |
| LUC7L2 | SRPK2 | ENSP00000347005 | ENSP00000377262 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | SRSF protein kinase 2 C-terminal; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates [...] | 0.968 |
| LUC7L2 | U2AF2 | ENSP00000347005 | ENSP00000307863 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | Splicing factor U2AF 65 kDa subunit; Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucl [...] | 0.997 |
