| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CNDP1 | MANEA | ENSP00000351682 | ENSP00000351669 | Carnosine dipeptidase 1; Belongs to the peptidase M20A family. | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | 0.632 |
| GMPS | MANEA | ENSP00000419851 | ENSP00000351669 | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | 0.670 |
| GMPS | RRM1 | ENSP00000419851 | ENSP00000300738 | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.626 |
| GRAMD1C | MANEA | ENSP00000350881 | ENSP00000351669 | Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol [...] | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | 0.535 |
| MAN1B1 | MANEA | ENSP00000360645 | ENSP00000351669 | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2); Belongs to the glycosyl hydrolase 47 family. | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | 0.930 |
| MAN1B1 | MOGS | ENSP00000360645 | ENSP00000410992 | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2); Belongs to the glycosyl hydrolase 47 family. | Mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner; Belongs to the glycosyl hydrolase 63 family. | 0.811 |
| MANEA | CNDP1 | ENSP00000351669 | ENSP00000351682 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | Carnosine dipeptidase 1; Belongs to the peptidase M20A family. | 0.632 |
| MANEA | GMPS | ENSP00000351669 | ENSP00000419851 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. | 0.670 |
| MANEA | GRAMD1C | ENSP00000351669 | ENSP00000350881 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol [...] | 0.535 |
| MANEA | MAN1B1 | ENSP00000351669 | ENSP00000360645 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2); Belongs to the glycosyl hydrolase 47 family. | 0.930 |
| MANEA | MOGS | ENSP00000351669 | ENSP00000410992 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | Mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner; Belongs to the glycosyl hydrolase 63 family. | 0.509 |
| MANEA | OLFM1 | ENSP00000351669 | ENSP00000360858 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | Noelin; Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity). | 0.601 |
| MANEA | RRM1 | ENSP00000351669 | ENSP00000300738 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.605 |
| MANEA | SCN3B | ENSP00000351669 | ENSP00000376523 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | Sodium channel subunit beta-3; Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). | 0.559 |
| MANEA | TRDN | ENSP00000351669 | ENSP00000333984 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | Triadin; Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. | 0.587 |
| MANEA | UGT1A10 | ENSP00000351669 | ENSP00000343838 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | UDP-glucuronosyltransferase 1-10; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. | 0.517 |
| MOGS | MAN1B1 | ENSP00000410992 | ENSP00000360645 | Mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner; Belongs to the glycosyl hydrolase 63 family. | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2); Belongs to the glycosyl hydrolase 47 family. | 0.811 |
| MOGS | MANEA | ENSP00000410992 | ENSP00000351669 | Mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner; Belongs to the glycosyl hydrolase 63 family. | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | 0.509 |
| OLFM1 | MANEA | ENSP00000360858 | ENSP00000351669 | Noelin; Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity). | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | 0.601 |
| RRM1 | GMPS | ENSP00000300738 | ENSP00000419851 | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. | 0.626 |