| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APOC1 | MPC2 | ENSP00000465356 | ENSP00000271373 | Truncated apolipoprotein C-I; Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the in [...] | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | 0.799 |
| FLOT2 | MPC2 | ENSP00000378368 | ENSP00000271373 | Flotillin-2; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function; Belongs to the band 7/mec-2 family. Flotillin subfamily. | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | 0.786 |
| HADHB | MPC2 | ENSP00000325136 | ENSP00000271373 | Trifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long- chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional en [...] | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | 0.787 |
| HADHB | NDUFB9 | ENSP00000325136 | ENSP00000276689 | Trifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long- chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional en [...] | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.550 |
| HADHB | SLC25A20 | ENSP00000325136 | ENSP00000326305 | Trifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long- chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional en [...] | Mitochondrial carnitine/acylcarnitine carrier protein; Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. | 0.717 |
| MICOS10 | MPC2 | ENSP00000325562 | ENSP00000271373 | MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | 0.647 |
| MICOS10 | NDUFB9 | ENSP00000325562 | ENSP00000276689 | MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.517 |
| MPC1 | MPC1L | ENSP00000354223 | ENSP00000489748 | Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. | Mitochondrial pyruvate carrier 1 like. | 0.904 |
| MPC1 | MPC2 | ENSP00000354223 | ENSP00000271373 | Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | 0.999 |
| MPC1 | NDUFS7 | ENSP00000354223 | ENSP00000233627 | Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.417 |
| MPC1L | MPC1 | ENSP00000489748 | ENSP00000354223 | Mitochondrial pyruvate carrier 1 like. | Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. | 0.904 |
| MPC1L | MPC2 | ENSP00000489748 | ENSP00000271373 | Mitochondrial pyruvate carrier 1 like. | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | 0.998 |
| MPC2 | APOC1 | ENSP00000271373 | ENSP00000465356 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | Truncated apolipoprotein C-I; Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the in [...] | 0.799 |
| MPC2 | FLOT2 | ENSP00000271373 | ENSP00000378368 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | Flotillin-2; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function; Belongs to the band 7/mec-2 family. Flotillin subfamily. | 0.786 |
| MPC2 | HADHB | ENSP00000271373 | ENSP00000325136 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | Trifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long- chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional en [...] | 0.787 |
| MPC2 | MICOS10 | ENSP00000271373 | ENSP00000325562 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. | 0.647 |
| MPC2 | MPC1 | ENSP00000271373 | ENSP00000354223 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. | 0.999 |
| MPC2 | MPC1L | ENSP00000271373 | ENSP00000489748 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | Mitochondrial pyruvate carrier 1 like. | 0.998 |
| MPC2 | NDUFB9 | ENSP00000271373 | ENSP00000276689 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.705 |
| MPC2 | NDUFS7 | ENSP00000271373 | ENSP00000233627 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.621 |