MRPL42 protein (human) - STRING interaction network

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Score

MRPL42

Mitochondrial ribosomal protein L42; Belongs to the mitochondrion-specific ribosomal protein mL42 family. (142 aa)

Predicted Functional Partners:

MRPL39

0.999

MRPL1

0.999

GADD45GIP1

0.999

MRPL41

0.999

MRPL47

0.999

MRPL22

0.999

MRPL32

0.998

MRPL3

0.998

MRPL40

0.998

MRPL52

0.998

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GADD45GIP1	MRPL1	ENSP00000323065	ENSP00000315017	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein L1.	0.881
GADD45GIP1	MRPL22	ENSP00000323065	ENSP00000431040	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein L22.	0.992
GADD45GIP1	MRPL3	ENSP00000323065	ENSP00000264995	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein L3.	0.992
GADD45GIP1	MRPL32	ENSP00000323065	ENSP00000223324	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family.	0.985
GADD45GIP1	MRPL39	ENSP00000323065	ENSP00000305682	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein L39; Belongs to the mitochondrion-specific ribosomal protein mL39 family.	0.989
GADD45GIP1	MRPL40	ENSP00000323065	ENSP00000333401	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family.	0.997
GADD45GIP1	MRPL41	ENSP00000323065	ENSP00000360498	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.	0.999
GADD45GIP1	MRPL42	ENSP00000323065	ENSP00000449884	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein L42; Belongs to the mitochondrion-specific ribosomal protein mL42 family.	0.999
GADD45GIP1	MRPL47	ENSP00000323065	ENSP00000417602	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein L47; Belongs to the universal ribosomal protein uL29 family.	0.999
GADD45GIP1	MRPL52	ENSP00000323065	ENSP00000347277	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein L52.	0.999
MRPL1	GADD45GIP1	ENSP00000315017	ENSP00000323065	Mitochondrial ribosomal protein L1.	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	0.881
MRPL1	MRPL22	ENSP00000315017	ENSP00000431040	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L22.	0.985
MRPL1	MRPL3	ENSP00000315017	ENSP00000264995	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L3.	0.991
MRPL1	MRPL32	ENSP00000315017	ENSP00000223324	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family.	0.975
MRPL1	MRPL39	ENSP00000315017	ENSP00000305682	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L39; Belongs to the mitochondrion-specific ribosomal protein mL39 family.	0.999
MRPL1	MRPL40	ENSP00000315017	ENSP00000333401	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family.	0.940
MRPL1	MRPL41	ENSP00000315017	ENSP00000360498	Mitochondrial ribosomal protein L1.	39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.	0.999
MRPL1	MRPL42	ENSP00000315017	ENSP00000449884	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L42; Belongs to the mitochondrion-specific ribosomal protein mL42 family.	0.999
MRPL1	MRPL47	ENSP00000315017	ENSP00000417602	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L47; Belongs to the universal ribosomal protein uL29 family.	0.998
MRPL1	MRPL52	ENSP00000315017	ENSP00000347277	Mitochondrial ribosomal protein L1.	Mitochondrial ribosomal protein L52.	0.999