Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NANOGNBNANOG neighbor homeobox. (188 aa)    
Predicted Functional Partners:
DPRX
Divergent paired-related homeobox; Putative transcription factor; Belongs to the paired homeobox family.
      
 0.713
DUXA
Double homeobox protein A; Putative transcription factor; Belongs to the paired homeobox family.
   
  
 0.594
TPRX1
Tetrapeptide repeat homeobox 1.
   
  
 0.589
ARGFX
Arginine-fifty homeobox; Putative transcription factor.
   
  
 0.587
GDF3
Growth/differentiation factor 3; Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto. Belongs to the TGF-beta family.
      
 0.571
DPPA3
Developmental pluripotency-associated protein 3; Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) o [...]
      
 0.545
DUXB
Double homeobox B.
      
 0.522
ANHX
Anomalous homeobox.
      
 0.497
PRAMEF17
PRAME family member 17; Belongs to the PRAME family.
      
 0.494
PRAMEF20
PRAME family member 20; Belongs to the PRAME family.
      
 0.485
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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