| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DRD5 | GPRIN2 | ENSP00000306129 | ENSP00000363436 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | 0.839 |
| DRD5 | GTF2I | ENSP00000306129 | ENSP00000460070 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | General transcription factor II-I; Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for [...] | 0.761 |
| DRD5 | HYDIN | ENSP00000306129 | ENSP00000377197 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | Hydrocephalus-inducing protein homolog; Required for ciliary motility. | 0.834 |
| DRD5 | NBPF1 | ENSP00000306129 | ENSP00000474456 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | Neuroblastoma breakpoint family member 1; NBPF member 1; Belongs to the NBPF family. | 0.822 |
| DRD5 | NPEPPS | ENSP00000306129 | ENSP00000320324 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | Puromycin-sensitive aminopeptidase; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. | 0.821 |
| DRD5 | SRGAP2 | ENSP00000306129 | ENSP00000459615 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] | 0.760 |
| DRD5 | SRGAP3 | ENSP00000306129 | ENSP00000373347 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | SLIT-ROBO Rho GTPase-activating protein 3; GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. | 0.768 |
| DRD5 | UGT2B17 | ENSP00000306129 | ENSP00000320401 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | UDP-glucuronosyltransferase 2B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4- methylumbelliferone > dihydrotestosterone (DHT) > androstane-3- alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT). | 0.824 |
| EVI5 | NBPF1 | ENSP00000440826 | ENSP00000474456 | Ecotropic viral integration site 5 protein homolog; Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis. | Neuroblastoma breakpoint family member 1; NBPF member 1; Belongs to the NBPF family. | 0.643 |
| GPRIN2 | DRD5 | ENSP00000363436 | ENSP00000306129 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | 0.839 |
| GPRIN2 | GTF2I | ENSP00000363436 | ENSP00000460070 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | General transcription factor II-I; Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for [...] | 0.775 |
| GPRIN2 | HYDIN | ENSP00000363436 | ENSP00000377197 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | Hydrocephalus-inducing protein homolog; Required for ciliary motility. | 0.866 |
| GPRIN2 | NBPF1 | ENSP00000363436 | ENSP00000474456 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | Neuroblastoma breakpoint family member 1; NBPF member 1; Belongs to the NBPF family. | 0.839 |
| GPRIN2 | NPEPPS | ENSP00000363436 | ENSP00000320324 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | Puromycin-sensitive aminopeptidase; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. | 0.833 |
| GPRIN2 | SRGAP2 | ENSP00000363436 | ENSP00000459615 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] | 0.855 |
| GPRIN2 | SRGAP3 | ENSP00000363436 | ENSP00000373347 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | SLIT-ROBO Rho GTPase-activating protein 3; GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. | 0.848 |
| GPRIN2 | UGT2B17 | ENSP00000363436 | ENSP00000320401 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | UDP-glucuronosyltransferase 2B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4- methylumbelliferone > dihydrotestosterone (DHT) > androstane-3- alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT). | 0.844 |
| GTF2I | DRD5 | ENSP00000460070 | ENSP00000306129 | General transcription factor II-I; Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for [...] | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | 0.761 |
| GTF2I | GPRIN2 | ENSP00000460070 | ENSP00000363436 | General transcription factor II-I; Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for [...] | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | 0.775 |
| GTF2I | HYDIN | ENSP00000460070 | ENSP00000377197 | General transcription factor II-I; Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for [...] | Hydrocephalus-inducing protein homolog; Required for ciliary motility. | 0.781 |
