Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NBPF4Neuroblastoma breakpoint family member 4; NBPF member 4. (638 aa)    
Predicted Functional Partners:
NBPF6
Neuroblastoma breakpoint family member 6; NBPF member 6.
  
  
0.978
RNF183
E3 ubiquitin-protein ligase RNF183; Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling.
   
   0.460
EFNA4
Ephrin-A4; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.
    
   0.457
PRR20A
Proline rich 20A.
      
 0.429
PRR20B
Proline-rich protein 20A; Proline rich 20B; Belongs to the PRR20 family.
      
 0.426
FAM47A
Protein FAM47A; Family with sequence similarity 47 member A.
  
    0.422
MAGEC1
Melanoma-associated antigen C1; MAGE family member C1.
  
  
 0.417
CPHXL
Cytoplasmic polyadenylated homeobox like.
  
 
 
 0.416
ENSP00000491197
Homeobox domain-containing protein.
  
 
 
 0.409
LRRC37A
Leucine-rich repeat-containing protein 37A; Leucine rich repeat containing 37A.
    
 
 0.404
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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