| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALS2 | CFAP410 | ENSP00000264276 | ENSP00000381047 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | Cilia and flagella associated protein 410. | 0.993 |
| ALS2 | CHCHD10 | ENSP00000264276 | ENSP00000384973 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial; May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. | 0.579 |
| ALS2 | NEK1 | ENSP00000264276 | ENSP00000424757 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | Serine/threonine-protein kinase Nek1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis (By similarity). Involved in cilium assembly. | 0.999 |
| ALS2 | YWHAH | ENSP00000264276 | ENSP00000248975 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | 14-3-3 protein eta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. | 0.589 |
| CFAP410 | ALS2 | ENSP00000381047 | ENSP00000264276 | Cilia and flagella associated protein 410. | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | 0.993 |
| CFAP410 | CHCHD10 | ENSP00000381047 | ENSP00000384973 | Cilia and flagella associated protein 410. | Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial; May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. | 0.628 |
| CFAP410 | NEK1 | ENSP00000381047 | ENSP00000424757 | Cilia and flagella associated protein 410. | Serine/threonine-protein kinase Nek1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis (By similarity). Involved in cilium assembly. | 0.980 |
| CFAP410 | SPATA7 | ENSP00000381047 | ENSP00000377176 | Cilia and flagella associated protein 410. | Spermatogenesis-associated protein 7; Involved in the maintenance of both rod and cone photoreceptor cells (By similarity). It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as photoreceptor-specific localization of proximal CC proteins at the distal CC (By similarity). Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration (By similarity). | 0.585 |
| CFAP410 | VTN | ENSP00000381047 | ENSP00000226218 | Cilia and flagella associated protein 410. | Vitronectin V10 subunit; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. | 0.864 |
| CFAP410 | YWHAH | ENSP00000381047 | ENSP00000248975 | Cilia and flagella associated protein 410. | 14-3-3 protein eta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. | 0.557 |
| CHCHD10 | ALS2 | ENSP00000384973 | ENSP00000264276 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial; May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | 0.579 |
| CHCHD10 | CFAP410 | ENSP00000384973 | ENSP00000381047 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial; May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. | Cilia and flagella associated protein 410. | 0.628 |
| CHCHD10 | NEK1 | ENSP00000384973 | ENSP00000424757 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial; May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. | Serine/threonine-protein kinase Nek1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis (By similarity). Involved in cilium assembly. | 0.769 |
| DYNC2H1 | NEK1 | ENSP00000497174 | ENSP00000424757 | Cytoplasmic dynein 2 heavy chain 1; May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity). | Serine/threonine-protein kinase Nek1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis (By similarity). Involved in cilium assembly. | 0.976 |
| LRRK1 | NEK1 | ENSP00000373600 | ENSP00000424757 | Leucine rich repeat kinase 1; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. | Serine/threonine-protein kinase Nek1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis (By similarity). Involved in cilium assembly. | 0.773 |
| ME1 | NEK1 | ENSP00000358719 | ENSP00000424757 | Malic enzyme 1. | Serine/threonine-protein kinase Nek1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis (By similarity). Involved in cilium assembly. | 0.821 |
| NEK1 | ALS2 | ENSP00000424757 | ENSP00000264276 | Serine/threonine-protein kinase Nek1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis (By similarity). Involved in cilium assembly. | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | 0.999 |
| NEK1 | CFAP410 | ENSP00000424757 | ENSP00000381047 | Serine/threonine-protein kinase Nek1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis (By similarity). Involved in cilium assembly. | Cilia and flagella associated protein 410. | 0.980 |
| NEK1 | CHCHD10 | ENSP00000424757 | ENSP00000384973 | Serine/threonine-protein kinase Nek1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis (By similarity). Involved in cilium assembly. | Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial; May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. | 0.769 |
| NEK1 | DYNC2H1 | ENSP00000424757 | ENSP00000497174 | Serine/threonine-protein kinase Nek1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis (By similarity). Involved in cilium assembly. | Cytoplasmic dynein 2 heavy chain 1; May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity). | 0.976 |
