Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NHLRC4NHL-repeat-containing protein 4; NHL repeat containing 4. (123 aa)    
Predicted Functional Partners:
PRR35
Proline-rich protein 35; Proline rich 35.
 
 
    0.816
TAC4
Endokinin-A/B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.
   
    0.690
P3R3URF
PIK3R3 upstream reading frame.
   
    0.643
C11orf45
Putative uncharacterized protein C11orf45; Chromosome 11 open reading frame 45.
   
  
 0.611
OR51M1
Olfactory receptor 51M1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
    0.593
GYPB
Glycophorin-B; This protein is a minor sialoglycoprotein in erythrocyte membranes; Belongs to the glycophorin-A family.
   
    0.588
PSORS1C1
Psoriasis susceptibility 1 candidate 1.
   
    0.587
SFTA3
Surfactant-associated protein 3; Putative surfactant protein. May be involved in wound healing and in the reduction of the surface tension at the ocular surface.
   
    0.575
SLN
Sarcolipin; Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle- based, non-shivering thermogenesis (By similarity). Belongs to the sarcolipin family.
   
    0.575
OR5T2
Olfactory receptor 5T2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
    0.569
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.