NLRP8 protein (human) - STRING interaction network

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NLRP8

NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation. (1048 aa)

Predicted Functional Partners:

MEFV

0.854

DNAJB4

0.820

DNAJB5

0.816

CASP1

0.576

SRGN

0.457

C19orf85

0.443

OR10P1

0.428

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C19orf85	NLRP8	ENSP00000490220	ENSP00000291971	Uncharacterized protein C19orf85; Chromosome 19 open reading frame 85.	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation.	0.443
CASP1	MEFV	ENSP00000433138	ENSP00000219596	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it [...]	0.999
CASP1	NLRP8	ENSP00000433138	ENSP00000291971	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation.	0.576
DNAJB4	DNAJB5	ENSP00000359799	ENSP00000404079	DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	DnaJ heat shock protein family member B5.	0.999
DNAJB4	NLRP8	ENSP00000359799	ENSP00000291971	DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation.	0.820
DNAJB5	DNAJB4	ENSP00000404079	ENSP00000359799	DnaJ heat shock protein family member B5.	DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	0.999
DNAJB5	NLRP8	ENSP00000404079	ENSP00000291971	DnaJ heat shock protein family member B5.	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation.	0.816
MEFV	CASP1	ENSP00000219596	ENSP00000433138	Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it [...]	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.999
MEFV	NLRP8	ENSP00000219596	ENSP00000291971	Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it [...]	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation.	0.854
NLRP8	C19orf85	ENSP00000291971	ENSP00000490220	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation.	Uncharacterized protein C19orf85; Chromosome 19 open reading frame 85.	0.443
NLRP8	CASP1	ENSP00000291971	ENSP00000433138	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.576
NLRP8	DNAJB4	ENSP00000291971	ENSP00000359799	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation.	DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).	0.820
NLRP8	DNAJB5	ENSP00000291971	ENSP00000404079	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation.	DnaJ heat shock protein family member B5.	0.816
NLRP8	MEFV	ENSP00000291971	ENSP00000219596	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation.	Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it [...]	0.854
NLRP8	OR10P1	ENSP00000291971	ENSP00000308082	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation.	Olfactory receptor 10P1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.428
NLRP8	SRGN	ENSP00000291971	ENSP00000242465	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation.	Serglycin; Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule- mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also r [...]	0.457
OR10P1	NLRP8	ENSP00000308082	ENSP00000291971	Olfactory receptor 10P1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation.	0.428
SRGN	NLRP8	ENSP00000242465	ENSP00000291971	Serglycin; Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule- mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also r [...]	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation.	0.457