| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DCC | DSCAM | ENSP00000389140 | ENSP00000383303 | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. | Down syndrome cell adhesion molecule; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self- avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collabor [...] | 0.956 |
| DCC | NTN5 | ENSP00000389140 | ENSP00000270235 | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. | Netrin-5; Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. | 0.457 |
| DCC | UNC5A | ENSP00000389140 | ENSP00000332737 | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. | Netrin receptor UNC5A; Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. | 0.986 |
| DCC | UNC5C | ENSP00000389140 | ENSP00000406022 | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. | Netrin receptor UNC5C; Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of D [...] | 0.987 |
| DSCAM | DCC | ENSP00000383303 | ENSP00000389140 | Down syndrome cell adhesion molecule; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self- avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collabor [...] | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. | 0.956 |
| DSCAM | NTN5 | ENSP00000383303 | ENSP00000270235 | Down syndrome cell adhesion molecule; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self- avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collabor [...] | Netrin-5; Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. | 0.480 |
| DSCAM | UNC5A | ENSP00000383303 | ENSP00000332737 | Down syndrome cell adhesion molecule; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self- avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collabor [...] | Netrin receptor UNC5A; Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. | 0.633 |
| DSCAM | UNC5C | ENSP00000383303 | ENSP00000406022 | Down syndrome cell adhesion molecule; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self- avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collabor [...] | Netrin receptor UNC5C; Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of D [...] | 0.577 |
| KCNJ14 | NTN5 | ENSP00000375756 | ENSP00000270235 | ATP-sensitive inward rectifier potassium channel 14; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium [...] | Netrin-5; Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. | 0.462 |
| LTBP1 | NTN5 | ENSP00000386043 | ENSP00000270235 | Latent-transforming growth factor beta-binding protein 1; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta. Belongs to the LTBP family. | Netrin-5; Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. | 0.464 |
| MYCBPAP | NTN5 | ENSP00000498665 | ENSP00000270235 | MYCBP-associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity). | Netrin-5; Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. | 0.466 |
| NTF4 | NTN5 | ENSP00000469455 | ENSP00000270235 | Neurotrophin-4; Target-derived survival factor for peripheral sensory sympathetic neurons. | Netrin-5; Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. | 0.461 |
| NTN5 | DCC | ENSP00000270235 | ENSP00000389140 | Netrin-5; Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. | 0.457 |
| NTN5 | DSCAM | ENSP00000270235 | ENSP00000383303 | Netrin-5; Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. | Down syndrome cell adhesion molecule; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self- avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collabor [...] | 0.480 |
| NTN5 | KCNJ14 | ENSP00000270235 | ENSP00000375756 | Netrin-5; Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. | ATP-sensitive inward rectifier potassium channel 14; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium [...] | 0.462 |
| NTN5 | LTBP1 | ENSP00000270235 | ENSP00000386043 | Netrin-5; Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. | Latent-transforming growth factor beta-binding protein 1; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta. Belongs to the LTBP family. | 0.464 |
| NTN5 | MYCBPAP | ENSP00000270235 | ENSP00000498665 | Netrin-5; Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. | MYCBP-associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity). | 0.466 |
| NTN5 | NTF4 | ENSP00000270235 | ENSP00000469455 | Netrin-5; Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. | Neurotrophin-4; Target-derived survival factor for peripheral sensory sympathetic neurons. | 0.461 |
| NTN5 | RTN4RL2 | ENSP00000270235 | ENSP00000335397 | Netrin-5; Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. | Reticulon-4 receptor-like 2; Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, pl [...] | 0.483 |
| NTN5 | TMEM19 | ENSP00000270235 | ENSP00000266673 | Netrin-5; Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. | Transmembrane protein 19. | 0.471 |
