Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NXPE4NXPE family member 4; Neurexophilin and PC-esterase domain family member 4; Belongs to the NXPE family. (544 aa)    
Predicted Functional Partners:
NXPE1
NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family.
  
  
0.786
MS4A12
Membrane-spanning 4-domains subfamily A member 12; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family.
   
  
 0.611
TRIM31
E3 ubiquitin-protein ligase TRIM31; Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity. Belongs to the TRIM/RBCC family.
   
   0.479
CEACAM7
CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family.
   
 
 0.445
CLCA1
Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
   
  
 0.436
REP15
Rab15 effector protein; Regulates transferrin receptor recycling from the endocytic recycling compartment.
      
 0.418
SAMD13
Sterile alpha motif domain containing 13.
   
  
 0.409
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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