PLAC9 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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experimentally determined

co-expression

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gene neighborhood

gene co-occurrence

gene fusions

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Score

PLAC9

Placenta-specific protein 9; Placenta associated 9; Belongs to the PLAC9 family. (97 aa)

Predicted Functional Partners:

EMILIN1

0.978

EMC6

0.663

TMEM254

0.570

DUXB

0.546

EMC3

0.539

DCN

0.522

DTWD1

0.487

FBLN2

0.468

ANXA11

0.462

DUXA

0.442

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA11	DUXA	ENSP00000398610	ENSP00000452398	Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.	Double homeobox protein A; Putative transcription factor; Belongs to the paired homeobox family.	0.484
ANXA11	PLAC9	ENSP00000398610	ENSP00000361337	Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.	Placenta-specific protein 9; Placenta associated 9; Belongs to the PLAC9 family.	0.462
ANXA11	TMEM254	ENSP00000398610	ENSP00000361355	Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.	Transmembrane protein 254.	0.485
DCN	EMILIN1	ENSP00000052754	ENSP00000369677	Decorin; May affect the rate of fibrils formation.	EMILIN-1; May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.	0.559
DCN	FBLN2	ENSP00000052754	ENSP00000384169	Decorin; May affect the rate of fibrils formation.	Fibulin-2; Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN.	0.676
DCN	PLAC9	ENSP00000052754	ENSP00000361337	Decorin; May affect the rate of fibrils formation.	Placenta-specific protein 9; Placenta associated 9; Belongs to the PLAC9 family.	0.522
DTWD1	PLAC9	ENSP00000251250	ENSP00000361337	DTW domain containing 1; Belongs to the DTW family.	Placenta-specific protein 9; Placenta associated 9; Belongs to the PLAC9 family.	0.487
DUXA	ANXA11	ENSP00000452398	ENSP00000398610	Double homeobox protein A; Putative transcription factor; Belongs to the paired homeobox family.	Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.	0.484
DUXA	PLAC9	ENSP00000452398	ENSP00000361337	Double homeobox protein A; Putative transcription factor; Belongs to the paired homeobox family.	Placenta-specific protein 9; Placenta associated 9; Belongs to the PLAC9 family.	0.442
DUXB	PLAC9	ENSP00000491301	ENSP00000361337	Double homeobox B.	Placenta-specific protein 9; Placenta associated 9; Belongs to the PLAC9 family.	0.546
DUXB	TMEM254	ENSP00000491301	ENSP00000361355	Double homeobox B.	Transmembrane protein 254.	0.469
EMC3	EMC6	ENSP00000245046	ENSP00000380322	ER membrane protein complex subunit 3.	ER membrane protein complex subunit 6; Belongs to the EMC6 family.	0.999
EMC3	PLAC9	ENSP00000245046	ENSP00000361337	ER membrane protein complex subunit 3.	Placenta-specific protein 9; Placenta associated 9; Belongs to the PLAC9 family.	0.539
EMC6	EMC3	ENSP00000380322	ENSP00000245046	ER membrane protein complex subunit 6; Belongs to the EMC6 family.	ER membrane protein complex subunit 3.	0.999
EMC6	PLAC9	ENSP00000380322	ENSP00000361337	ER membrane protein complex subunit 6; Belongs to the EMC6 family.	Placenta-specific protein 9; Placenta associated 9; Belongs to the PLAC9 family.	0.663
EMILIN1	DCN	ENSP00000369677	ENSP00000052754	EMILIN-1; May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.	Decorin; May affect the rate of fibrils formation.	0.559
EMILIN1	PLAC9	ENSP00000369677	ENSP00000361337	EMILIN-1; May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.	Placenta-specific protein 9; Placenta associated 9; Belongs to the PLAC9 family.	0.978
FBLN2	DCN	ENSP00000384169	ENSP00000052754	Fibulin-2; Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN.	Decorin; May affect the rate of fibrils formation.	0.676
FBLN2	PLAC9	ENSP00000384169	ENSP00000361337	Fibulin-2; Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN.	Placenta-specific protein 9; Placenta associated 9; Belongs to the PLAC9 family.	0.468
PLAC9	ANXA11	ENSP00000361337	ENSP00000398610	Placenta-specific protein 9; Placenta associated 9; Belongs to the PLAC9 family.	Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.	0.462