PRAMEF17 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

PRAMEF17

PRAME family member 17; Belongs to the PRAME family. (474 aa)

Predicted Functional Partners:

PRAMEF10

0.999

PRAMEF12

0.987

PRAMEF2

0.986

PRAMEF14

0.986

PRAMEF1

0.985

PRAMEF8

0.963

PRAMEF7

0.960

CUL2

0.934

PRAMEF20

0.912

PRAMEF18

0.911

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUL2	PRAMEF1	ENSP00000414095	ENSP00000332134	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the denedd [...]	PRAME family member 1; Belongs to the PRAME family.	0.905
CUL2	PRAMEF10	ENSP00000414095	ENSP00000235347	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the denedd [...]	PRAME family member 10; Belongs to the PRAME family.	0.900
CUL2	PRAMEF12	ENSP00000414095	ENSP00000350358	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the denedd [...]	PRAME family member 12; Belongs to the PRAME family.	0.911
CUL2	PRAMEF14	ENSP00000414095	ENSP00000334410	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the denedd [...]	PRAME family member 14.	0.905
CUL2	PRAMEF17	ENSP00000414095	ENSP00000365266	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the denedd [...]	PRAME family member 17; Belongs to the PRAME family.	0.934
CUL2	PRAMEF18	ENSP00000414095	ENSP00000485473	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the denedd [...]	PRAME family member 18; Belongs to the PRAME family.	0.900
CUL2	PRAMEF2	ENSP00000414095	ENSP00000240189	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the denedd [...]	PRAME family member 2; Belongs to the PRAME family.	0.951
CUL2	PRAMEF20	ENSP00000414095	ENSP00000346275	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the denedd [...]	PRAME family member 20; Belongs to the PRAME family.	0.905
CUL2	PRAMEF7	ENSP00000414095	ENSP00000484237	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the denedd [...]	PRAME family member 7; Belongs to the PRAME family.	0.905
CUL2	PRAMEF8	ENSP00000414095	ENSP00000349931	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the denedd [...]	PRAME family member 8; Belongs to the PRAME family.	0.905
PRAMEF1	CUL2	ENSP00000332134	ENSP00000414095	PRAME family member 1; Belongs to the PRAME family.	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the denedd [...]	0.905
PRAMEF1	PRAMEF10	ENSP00000332134	ENSP00000235347	PRAME family member 1; Belongs to the PRAME family.	PRAME family member 10; Belongs to the PRAME family.	0.988
PRAMEF1	PRAMEF12	ENSP00000332134	ENSP00000350358	PRAME family member 1; Belongs to the PRAME family.	PRAME family member 12; Belongs to the PRAME family.	0.992
PRAMEF1	PRAMEF14	ENSP00000332134	ENSP00000334410	PRAME family member 1; Belongs to the PRAME family.	PRAME family member 14.	0.993
PRAMEF1	PRAMEF17	ENSP00000332134	ENSP00000365266	PRAME family member 1; Belongs to the PRAME family.	PRAME family member 17; Belongs to the PRAME family.	0.985
PRAMEF1	PRAMEF18	ENSP00000332134	ENSP00000485473	PRAME family member 1; Belongs to the PRAME family.	PRAME family member 18; Belongs to the PRAME family.	0.907
PRAMEF1	PRAMEF2	ENSP00000332134	ENSP00000240189	PRAME family member 1; Belongs to the PRAME family.	PRAME family member 2; Belongs to the PRAME family.	0.993
PRAMEF1	PRAMEF20	ENSP00000332134	ENSP00000346275	PRAME family member 1; Belongs to the PRAME family.	PRAME family member 20; Belongs to the PRAME family.	0.906
PRAMEF1	PRAMEF7	ENSP00000332134	ENSP00000484237	PRAME family member 1; Belongs to the PRAME family.	PRAME family member 7; Belongs to the PRAME family.	0.985
PRAMEF1	PRAMEF8	ENSP00000332134	ENSP00000349931	PRAME family member 1; Belongs to the PRAME family.	PRAME family member 8; Belongs to the PRAME family.	0.985