Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PRAMEF20PRAME family member 20; Belongs to the PRAME family. (475 aa)    
Predicted Functional Partners:
PRAMEF15
PRAME family member 15; Belongs to the PRAME family.
  
 
 
0.985
PRAMEF6
PRAME family member 6; Belongs to the PRAME family.
  
 
 
0.985
PRAMEF5
PRAME family member 5; Belongs to the PRAME family.
  
 
 
0.985
PRAMEF4
PRAME family member 4; Belongs to the PRAME family.
  
 
 
0.984
PRAMEF27
PRAME family member 27; Belongs to the PRAME family.
  
 
 
0.984
PRAMEF11
PRAME family member 11; Belongs to the PRAME family.
  
 
 
0.984
ZER1
Protein zer-1 homolog; Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation.
     
 0.933
PRAMEF25
PRAME family member 25; Belongs to the PRAME family.
  
 
 
0.922
PRAMEF18
PRAME family member 18; Belongs to the PRAME family.
  
 
0.921
PRAMEF12
PRAME family member 12; Belongs to the PRAME family.
  
 
 
0.920
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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