Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PRAMEF9PRAME family member 9. (478 aa)    
Predicted Functional Partners:
SUPT20H
Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. Belongs to the SPT20 family.
    
   0.745
MRPL17
Mitochondrial ribosomal protein L17.
  
 
 0.622
MRPS9
Mitochondrial ribosomal protein S9.
  
 
 0.617
PRAMEF4
PRAME family member 4; Belongs to the PRAME family.
  
0.609
MRPL36
Mitochondrial ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.
  
 
 0.608
RPL23
Ribosomal protein L23.
  
 
 0.607
MRPS6
Mitochondrial ribosomal protein S6.
   
 
 0.604
MRPL20
Mitochondrial ribosomal protein L20.
   
 
 0.598
MRPS16
Mitochondrial ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family.
   
 
 0.598
RPS18
40S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.
  
 
 0.597
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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