Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PROX2Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity). Belongs to the Prospero homeodomain family. (592 aa)    
Predicted Functional Partners:
VRTN
Vertnin; Vertebrae development associated; Belongs to the vertnin family.
      
 0.716
ANKRD61
Ankyrin repeat domain 61.
   
  
 0.586
AREL1
Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation.
      
 0.553
FAM110D
Protein FAM110D; Family with sequence similarity 110 member D; Belongs to the FAM110 family.
      
 0.539
SYNDIG1L
Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like.
      
 0.535
YLPM1
YLP motif-containing protein 1; Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.
      
 0.519
CTXN1
Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development; Belongs to the cortexin family.
      
 0.499
HEATR4
HEAT repeat containing 4.
   
  
 0.499
MANSC4
MANSC domain containing 4.
      
 0.474
FCF1
rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly; Belongs to the UTP23/FCF1 family. FCF1 subfamily.
      
 0.444
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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