| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LUC7L | LUC7L3 | ENSP00000293872 | ENSP00000376919 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | 0.983 |
| LUC7L | PRPF39 | ENSP00000293872 | ENSP00000348010 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing. | 0.979 |
| LUC7L | SF3B1 | ENSP00000293872 | ENSP00000335321 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). May also be involved [...] | 0.969 |
| LUC7L | SNRNP70 | ENSP00000293872 | ENSP00000472998 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. | 0.997 |
| LUC7L | SNRPC | ENSP00000293872 | ENSP00000244520 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] | 0.991 |
| LUC7L | SNRPD1 | ENSP00000293872 | ENSP00000300413 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with R [...] | 0.994 |
| LUC7L | SNRPF | ENSP00000293872 | ENSP00000266735 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Small nuclear ribonucleoprotein F; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. | 0.975 |
| LUC7L | SNRPN | ENSP00000293872 | ENSP00000494831 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events. | 0.972 |
| LUC7L | TRNAU1AP | ENSP00000293872 | ENSP00000362936 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | tRNA selenocysteine 1-associated protein 1; Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity); Belongs to the RRM TRSPAP family. | 0.450 |
| LUC7L | U2AF2 | ENSP00000293872 | ENSP00000307863 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Splicing factor U2AF 65 kDa subunit; Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucl [...] | 0.987 |
| LUC7L3 | LUC7L | ENSP00000376919 | ENSP00000293872 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | 0.983 |
| LUC7L3 | PRPF39 | ENSP00000376919 | ENSP00000348010 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing. | 0.977 |
| LUC7L3 | SF3B1 | ENSP00000376919 | ENSP00000335321 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). May also be involved [...] | 0.975 |
| LUC7L3 | SNRNP70 | ENSP00000376919 | ENSP00000472998 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. | 0.980 |
| LUC7L3 | SNRPC | ENSP00000376919 | ENSP00000244520 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] | 0.968 |
| LUC7L3 | SNRPD1 | ENSP00000376919 | ENSP00000300413 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with R [...] | 0.944 |
| LUC7L3 | SNRPF | ENSP00000376919 | ENSP00000266735 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Small nuclear ribonucleoprotein F; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. | 0.967 |
| LUC7L3 | SNRPN | ENSP00000376919 | ENSP00000494831 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events. | 0.936 |
| LUC7L3 | U2AF2 | ENSP00000376919 | ENSP00000307863 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Splicing factor U2AF 65 kDa subunit; Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucl [...] | 0.973 |
| PRPF39 | LUC7L | ENSP00000348010 | ENSP00000293872 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing. | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | 0.979 |
