Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PRR35Proline-rich protein 35; Proline rich 35. (571 aa)    
Predicted Functional Partners:
NHLRC4
NHL-repeat-containing protein 4; NHL repeat containing 4.
 
 
    0.816
OR51A4
Olfactory receptor 51A4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.659
OR52J3
Olfactory receptor 52J3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.649
OR51A2
Olfactory receptor 51A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.630
OR51L1
Olfactory receptor 51L1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.630
SPATA48
Spermatogenesis-associated protein 48; Spermatogenesis associated 48.
      
 0.615
RRP36
Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. Belongs to the RRP36 family.
      
 0.607
KBTBD12
Kelch repeat and BTB domain containing 12.
      
 0.597
KLHDC8B
Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells.
      
 0.570
TOGARAM1
TOG array regulator of axonemal microtubules protein 1; Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity). Belongs to the Crescerin family.
      
 0.566
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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