Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PSG1Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family. (428 aa)    
Predicted Functional Partners:
PSG3
Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family.
  
 
0.999
PSG9
Pregnancy specific beta-1-glycoprotein 9.
  
 
0.994
PSG8
Pregnancy specific beta-1-glycoprotein 8.
  
 
0.982
MEGF8
Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling.
    
 
 0.946
PSG4
Pregnancy specific beta-1-glycoprotein 4.
  
 
0.935
ANKRD46
Ankyrin repeat domain 46.
    
   0.930
PSG6
Pregnancy specific beta-1-glycoprotein 6.
  
 
0.927
IKBKB
Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated [...]
    
   0.874
TGFB1
Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]
    
 0.863
PSG2
Pregnancy specific beta-1-glycoprotein 2.
  
  
0.833
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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