PSG3 protein (human) - STRING interaction network

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[Homology]

Score

PSG3

Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family. (428 aa)

Predicted Functional Partners:

PSG1

0.999

PSG9

0.998

ANKRD46

0.994

PSG6

0.992

PSG8

0.960

MEGF8

0.958

PSG4

0.915

CEACAM7

0.880

PSG5

0.869

MGRN1

0.857

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD46	MEGF8	ENSP00000429015	ENSP00000251268	Ankyrin repeat domain 46.	Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling.	0.933
ANKRD46	MGRN1	ENSP00000429015	ENSP00000262370	Ankyrin repeat domain 46.	E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS- binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).	0.999
ANKRD46	PSG1	ENSP00000429015	ENSP00000308970	Ankyrin repeat domain 46.	Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family.	0.930
ANKRD46	PSG3	ENSP00000429015	ENSP00000332215	Ankyrin repeat domain 46.	Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family.	0.994
ANKRD46	PSG8	ENSP00000429015	ENSP00000305005	Ankyrin repeat domain 46.	Pregnancy specific beta-1-glycoprotein 8.	0.515
CEACAM7	PSG3	ENSP00000006724	ENSP00000332215	CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family.	Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family.	0.880
CEACAM7	PSG6	ENSP00000006724	ENSP00000292125	CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family.	Pregnancy specific beta-1-glycoprotein 6.	0.882
MEGF8	ANKRD46	ENSP00000251268	ENSP00000429015	Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling.	Ankyrin repeat domain 46.	0.933
MEGF8	MGRN1	ENSP00000251268	ENSP00000262370	Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling.	E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS- binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).	0.999
MEGF8	PSG1	ENSP00000251268	ENSP00000308970	Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling.	Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family.	0.946
MEGF8	PSG3	ENSP00000251268	ENSP00000332215	Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling.	Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family.	0.958
MEGF8	PSG8	ENSP00000251268	ENSP00000305005	Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling.	Pregnancy specific beta-1-glycoprotein 8.	0.990
MGRN1	ANKRD46	ENSP00000262370	ENSP00000429015	E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS- binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).	Ankyrin repeat domain 46.	0.999
MGRN1	MEGF8	ENSP00000262370	ENSP00000251268	E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS- binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).	Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling.	0.999
MGRN1	PSG1	ENSP00000262370	ENSP00000308970	E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS- binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).	Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family.	0.542
MGRN1	PSG3	ENSP00000262370	ENSP00000332215	E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS- binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).	Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family.	0.857
MGRN1	PSG8	ENSP00000262370	ENSP00000305005	E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS- binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).	Pregnancy specific beta-1-glycoprotein 8.	0.953
PSG1	ANKRD46	ENSP00000308970	ENSP00000429015	Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family.	Ankyrin repeat domain 46.	0.930
PSG1	MEGF8	ENSP00000308970	ENSP00000251268	Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family.	Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling.	0.946
PSG1	MGRN1	ENSP00000308970	ENSP00000262370	Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family.	E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS- binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).	0.542