Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
PSORS1C1Psoriasis susceptibility 1 candidate 1. (152 aa)    
Predicted Functional Partners:
CDSN
Corneodesmosin; Important for the epidermal barrier integrity.
   
  
 0.946
PSORS1C2
Psoriasis susceptibility 1 candidate 2.
   
  
 0.758
HLA-C
HLA class I histocompatibility antigen, C alpha chain; Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity. In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells. In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary [...]
      
 0.739
CCHCR1
Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation.
      
 0.675
OR5T2
Olfactory receptor 5T2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.666
OR1J4
Olfactory receptor 1J4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.649
OR51M1
Olfactory receptor 51M1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
    0.645
TAC4
Endokinin-A/B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.
   
    0.616
SFTA2
Surfactant-associated protein 2; Putative surfactant protein.
   
  
 0.606
TCF19
Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.
      
 0.606
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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