Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PSORS1C2Psoriasis susceptibility 1 candidate 2. (136 aa)    
Predicted Functional Partners:
VASP
Vasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end [...]
   
   0.800
CCHCR1
Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation.
 
    
 0.761
PSORS1C1
Psoriasis susceptibility 1 candidate 1.
   
  
 0.758
CDSN
Corneodesmosin; Important for the epidermal barrier integrity.
   
  
 0.699
TCF19
Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.
    
 
 0.547
RPRML
Reprimo-like protein; Reprimo like.
   
    0.544
SERTAD3
SERTA domain-containing protein 3; Strong transcriptional coactivator.
   
    0.544
C6orf15
Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15.
   
  
 0.526
SAPCD1
Suppressor APC domain containing 1.
      
 0.488
TGM5
Protein-glutamine gamma-glutamyltransferase 5; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes; Belongs to the transglutaminase superfamily. Transglutaminase family.
   
  
 0.468
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.