Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RFPL4ARet finger protein like 4A. (287 aa)    
Predicted Functional Partners:
RFPL4B
Ret finger protein like 4B.
   
  
0.999
FAM90A1
Protein FAM90A1; Family with sequence similarity 90 member A1.
    
   0.999
RFPL4AL1
Ret finger protein like 4A like 1.
  
 
0.991
GDF9
Growth/differentiation factor 9; Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. [...]
      
 0.872
KCNRG
Potassium channel regulatory protein; Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.
    
   0.531
OOSP1
Putative oocyte-secreted protein 1 homolog; May be involved in cell differentiation; Belongs to the PLAC1 family.
      
 0.465
C19orf85
Uncharacterized protein C19orf85; Chromosome 19 open reading frame 85.
      
 0.439
ZSCAN5A
Zinc finger and SCAN domain-containing protein 5A; May be involved in transcriptional regulation.
      
 0.432
NOBOX
Homeobox protein NOBOX; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'.
   
  
 0.417
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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