| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCZ1 | CCZ1B | ENSP00000325681 | ENSP00000314544 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | 0.949 |
| CCZ1 | MON1A | ENSP00000325681 | ENSP00000296473 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity). Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | 0.999 |
| CCZ1 | MON1B | ENSP00000325681 | ENSP00000248248 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | MON1 homolog B, secretory trafficking associated; Belongs to the MON1/SAND family. | 0.995 |
| CCZ1 | RAB7A | ENSP00000325681 | ENSP00000265062 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulat [...] | 0.993 |
| CCZ1 | RMC1 | ENSP00000325681 | ENSP00000269221 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | Regulator of MON1-CCZ1 complex; Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization. | 0.999 |
| CCZ1 | SP6 | ENSP00000325681 | ENSP00000438209 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | Transcription factor Sp6; Promotes cell proliferation; Belongs to the Sp1 C2H2-type zinc-finger protein family. | 0.816 |
| CCZ1B | CCZ1 | ENSP00000314544 | ENSP00000325681 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | 0.949 |
| CCZ1B | LAMTOR4 | ENSP00000314544 | ENSP00000343118 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | Ragulator complex protein LAMTOR4, N-terminally processed; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated; Belongs to the LAMTOR4 family. | 0.461 |
| CCZ1B | MON1A | ENSP00000314544 | ENSP00000296473 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity). Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | 0.999 |
| CCZ1B | MON1B | ENSP00000314544 | ENSP00000248248 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | MON1 homolog B, secretory trafficking associated; Belongs to the MON1/SAND family. | 0.993 |
| CCZ1B | RAB7A | ENSP00000314544 | ENSP00000265062 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulat [...] | 0.995 |
| CCZ1B | RIC1 | ENSP00000314544 | ENSP00000416696 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. | 0.524 |
| CCZ1B | RMC1 | ENSP00000314544 | ENSP00000269221 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | Regulator of MON1-CCZ1 complex; Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization. | 0.975 |
| DARS1 | RMC1 | ENSP00000264161 | ENSP00000269221 | Aspartate--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. | Regulator of MON1-CCZ1 complex; Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization. | 0.779 |
| LAMTOR4 | CCZ1B | ENSP00000343118 | ENSP00000314544 | Ragulator complex protein LAMTOR4, N-terminally processed; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated; Belongs to the LAMTOR4 family. | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated. | 0.461 |
| LAMTOR4 | MON1A | ENSP00000343118 | ENSP00000296473 | Ragulator complex protein LAMTOR4, N-terminally processed; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated; Belongs to the LAMTOR4 family. | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity). Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | 0.720 |
| LAMTOR4 | MON1B | ENSP00000343118 | ENSP00000248248 | Ragulator complex protein LAMTOR4, N-terminally processed; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated; Belongs to the LAMTOR4 family. | MON1 homolog B, secretory trafficking associated; Belongs to the MON1/SAND family. | 0.729 |
| LAMTOR4 | RIC1 | ENSP00000343118 | ENSP00000416696 | Ragulator complex protein LAMTOR4, N-terminally processed; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated; Belongs to the LAMTOR4 family. | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. | 0.725 |
| LAMTOR4 | RMC1 | ENSP00000343118 | ENSP00000269221 | Ragulator complex protein LAMTOR4, N-terminally processed; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated; Belongs to the LAMTOR4 family. | Regulator of MON1-CCZ1 complex; Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization. | 0.736 |
| MON1A | CCZ1 | ENSP00000296473 | ENSP00000325681 | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity). Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. | 0.999 |
