RNF148 protein (human) - STRING interaction network

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Score

RNF148

Ring finger protein 148. (305 aa)

Predicted Functional Partners:

RNF133

0.981

ZSWIM2

0.597

HERC5

0.505

RNF151

0.470

FAM24A

0.428

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAM24A	RNF148	ENSP00000357889	ENSP00000388207	Protein FAM24A; Family with sequence similarity 24 member A.	Ring finger protein 148.	0.428
HERC5	RNF148	ENSP00000264350	ENSP00000388207	E3 ISG15--protein ligase HERC5; Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimer [...]	Ring finger protein 148.	0.505
RNF133	RNF148	ENSP00000344489	ENSP00000388207	E3 ubiquitin-protein ligase RNF133; Has E3 ubiquitin-protein ligase activity.	Ring finger protein 148.	0.981
RNF133	RNF151	ENSP00000344489	ENSP00000456566	E3 ubiquitin-protein ligase RNF133; Has E3 ubiquitin-protein ligase activity.	RING finger protein 151; May be involved in acrosome formation of spermatids.	0.547
RNF133	ZSWIM2	ENSP00000344489	ENSP00000295131	E3 ubiquitin-protein ligase RNF133; Has E3 ubiquitin-protein ligase activity.	E3 ubiquitin-protein ligase ZSWIM2; E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.	0.443
RNF148	FAM24A	ENSP00000388207	ENSP00000357889	Ring finger protein 148.	Protein FAM24A; Family with sequence similarity 24 member A.	0.428
RNF148	HERC5	ENSP00000388207	ENSP00000264350	Ring finger protein 148.	E3 ISG15--protein ligase HERC5; Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimer [...]	0.505
RNF148	RNF133	ENSP00000388207	ENSP00000344489	Ring finger protein 148.	E3 ubiquitin-protein ligase RNF133; Has E3 ubiquitin-protein ligase activity.	0.981
RNF148	RNF151	ENSP00000388207	ENSP00000456566	Ring finger protein 148.	RING finger protein 151; May be involved in acrosome formation of spermatids.	0.470
RNF148	ZSWIM2	ENSP00000388207	ENSP00000295131	Ring finger protein 148.	E3 ubiquitin-protein ligase ZSWIM2; E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.	0.597
RNF151	RNF133	ENSP00000456566	ENSP00000344489	RING finger protein 151; May be involved in acrosome formation of spermatids.	E3 ubiquitin-protein ligase RNF133; Has E3 ubiquitin-protein ligase activity.	0.547
RNF151	RNF148	ENSP00000456566	ENSP00000388207	RING finger protein 151; May be involved in acrosome formation of spermatids.	Ring finger protein 148.	0.470
RNF151	ZSWIM2	ENSP00000456566	ENSP00000295131	RING finger protein 151; May be involved in acrosome formation of spermatids.	E3 ubiquitin-protein ligase ZSWIM2; E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.	0.545
ZSWIM2	RNF133	ENSP00000295131	ENSP00000344489	E3 ubiquitin-protein ligase ZSWIM2; E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.	E3 ubiquitin-protein ligase RNF133; Has E3 ubiquitin-protein ligase activity.	0.443
ZSWIM2	RNF148	ENSP00000295131	ENSP00000388207	E3 ubiquitin-protein ligase ZSWIM2; E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.	Ring finger protein 148.	0.597
ZSWIM2	RNF151	ENSP00000295131	ENSP00000456566	E3 ubiquitin-protein ligase ZSWIM2; E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.	RING finger protein 151; May be involved in acrosome formation of spermatids.	0.545