Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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RTP2Receptor-transporting protein 2; Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs. (225 aa)    
Predicted Functional Partners:
REEP1
Receptor expression-enhancing protein 1; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors. May play a role in long-term axonal maintenance.
     
 0.979
RTP1
Receptor-transporting protein 1; Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs; Belongs to the TMEM7 family.
  
 
0.824
OR11H4
Olfactory receptor 11H4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
 0.754
CNGA2
Cyclic nucleotide-gated olfactory channel; Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily.
   
  
 0.733
CNGA4
Cyclic nucleotide-gated cation channel alpha-4; Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity).
   
  
 0.679
OR7D4
Olfactory receptor 7D4; Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.
   
 0.673
OR2A7
Olfactory receptor 2A7; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
    
 0.636
OR2L13
Olfactory receptor 2L13; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
 0.623
OR5D18
Olfactory receptor 5D18; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
 0.612
OR6A2
Olfactory receptor 6A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
 0.603
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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