SEC14L5 protein (human) - STRING interaction network

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Score

SEC14L5

SEC14-like protein 5; SEC14 like lipid binding 5. (696 aa)

Predicted Functional Partners:

ALG1

0.951

FOXA1

0.460

MEX3A

0.457

CCDC73

0.429

PACSIN1

0.424

ANO3

0.416

HAPLN2

0.406

PRSS33

0.405

HUNK

0.401

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALG1	SEC14L5	ENSP00000262374	ENSP00000251170	Chitobiosyldiphosphodolichol beta-mannosyltransferase; Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily.	SEC14-like protein 5; SEC14 like lipid binding 5.	0.951
ANO3	SEC14L5	ENSP00000256737	ENSP00000251170	Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity.	SEC14-like protein 5; SEC14 like lipid binding 5.	0.416
CCDC73	SEC14L5	ENSP00000335325	ENSP00000251170	Coiled-coil domain containing 73.	SEC14-like protein 5; SEC14 like lipid binding 5.	0.429
FOXA1	SEC14L5	ENSP00000250448	ENSP00000251170	Hepatocyte nuclear factor 3-alpha; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'- [AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures [...]	SEC14-like protein 5; SEC14 like lipid binding 5.	0.460
HAPLN2	SEC14L5	ENSP00000255039	ENSP00000251170	Hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity).	SEC14-like protein 5; SEC14 like lipid binding 5.	0.406
HUNK	SEC14L5	ENSP00000270112	ENSP00000251170	Hormonally up-regulated Neu-associated kinase.	SEC14-like protein 5; SEC14 like lipid binding 5.	0.401
MEX3A	SEC14L5	ENSP00000432845	ENSP00000251170	RNA-binding protein MEX3A; RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.	SEC14-like protein 5; SEC14 like lipid binding 5.	0.457
PACSIN1	SEC14L5	ENSP00000484060	ENSP00000251170	Protein kinase C and casein kinase substrate in neurons protein 1; Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching [...]	SEC14-like protein 5; SEC14 like lipid binding 5.	0.424
PRSS33	SEC14L5	ENSP00000293851	ENSP00000251170	Serine protease 33; Serine protease that has amidolytic activity, cleaving its substrates before Arg residues.	SEC14-like protein 5; SEC14 like lipid binding 5.	0.405
SEC14L5	ALG1	ENSP00000251170	ENSP00000262374	SEC14-like protein 5; SEC14 like lipid binding 5.	Chitobiosyldiphosphodolichol beta-mannosyltransferase; Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily.	0.951
SEC14L5	ANO3	ENSP00000251170	ENSP00000256737	SEC14-like protein 5; SEC14 like lipid binding 5.	Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity.	0.416
SEC14L5	CCDC73	ENSP00000251170	ENSP00000335325	SEC14-like protein 5; SEC14 like lipid binding 5.	Coiled-coil domain containing 73.	0.429
SEC14L5	FOXA1	ENSP00000251170	ENSP00000250448	SEC14-like protein 5; SEC14 like lipid binding 5.	Hepatocyte nuclear factor 3-alpha; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'- [AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures [...]	0.460
SEC14L5	HAPLN2	ENSP00000251170	ENSP00000255039	SEC14-like protein 5; SEC14 like lipid binding 5.	Hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity).	0.406
SEC14L5	HUNK	ENSP00000251170	ENSP00000270112	SEC14-like protein 5; SEC14 like lipid binding 5.	Hormonally up-regulated Neu-associated kinase.	0.401
SEC14L5	MEX3A	ENSP00000251170	ENSP00000432845	SEC14-like protein 5; SEC14 like lipid binding 5.	RNA-binding protein MEX3A; RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.	0.457
SEC14L5	PACSIN1	ENSP00000251170	ENSP00000484060	SEC14-like protein 5; SEC14 like lipid binding 5.	Protein kinase C and casein kinase substrate in neurons protein 1; Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching [...]	0.424
SEC14L5	PRSS33	ENSP00000251170	ENSP00000293851	SEC14-like protein 5; SEC14 like lipid binding 5.	Serine protease 33; Serine protease that has amidolytic activity, cleaving its substrates before Arg residues.	0.405