| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BCR | GRB2 | ENSP00000303507 | ENSP00000376345 | Breakpoint cluster region protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound t [...] | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family. | 0.999 |
| BCR | PDZK1 | ENSP00000303507 | ENSP00000342143 | Breakpoint cluster region protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound t [...] | Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resista [...] | 0.802 |
| BCR | SH2D5 | ENSP00000303507 | ENSP00000406026 | Breakpoint cluster region protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound t [...] | SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. | 0.640 |
| CTXN1 | FRRS1L | ENSP00000313226 | ENSP00000477141 | Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development; Belongs to the cortexin family. | DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway. | 0.482 |
| CTXN1 | RPRML | ENSP00000313226 | ENSP00000318032 | Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development; Belongs to the cortexin family. | Reprimo-like protein; Reprimo like. | 0.461 |
| CTXN1 | SH2D5 | ENSP00000313226 | ENSP00000406026 | Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development; Belongs to the cortexin family. | SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. | 0.524 |
| FRRS1L | CTXN1 | ENSP00000477141 | ENSP00000313226 | DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway. | Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development; Belongs to the cortexin family. | 0.482 |
| FRRS1L | SH2D5 | ENSP00000477141 | ENSP00000406026 | DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway. | SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. | 0.472 |
| GRB2 | BCR | ENSP00000376345 | ENSP00000303507 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family. | Breakpoint cluster region protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound t [...] | 0.999 |
| GRB2 | PDZK1 | ENSP00000376345 | ENSP00000342143 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family. | Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resista [...] | 0.490 |
| GRB2 | SH2D5 | ENSP00000376345 | ENSP00000406026 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family. | SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. | 0.456 |
| PDZK1 | BCR | ENSP00000342143 | ENSP00000303507 | Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resista [...] | Breakpoint cluster region protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound t [...] | 0.802 |
| PDZK1 | GRB2 | ENSP00000342143 | ENSP00000376345 | Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resista [...] | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family. | 0.490 |
| PDZK1 | SH2D5 | ENSP00000342143 | ENSP00000406026 | Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resista [...] | SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. | 0.588 |
| PRSS51 | SH2D5 | ENSP00000497613 | ENSP00000406026 | Serine protease 51. | SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. | 0.466 |
| RPRML | CTXN1 | ENSP00000318032 | ENSP00000313226 | Reprimo-like protein; Reprimo like. | Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development; Belongs to the cortexin family. | 0.461 |
| RPRML | SH2D5 | ENSP00000318032 | ENSP00000406026 | Reprimo-like protein; Reprimo like. | SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. | 0.516 |
| SH2D5 | BCR | ENSP00000406026 | ENSP00000303507 | SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. | Breakpoint cluster region protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound t [...] | 0.640 |
| SH2D5 | CTXN1 | ENSP00000406026 | ENSP00000313226 | SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. | Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development; Belongs to the cortexin family. | 0.524 |
| SH2D5 | FRRS1L | ENSP00000406026 | ENSP00000477141 | SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. | DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway. | 0.472 |
