Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SMIM7Small integral membrane protein 7. (103 aa)    
Predicted Functional Partners:
PPWD1
Peptidylprolyl isomerase domain and WD repeat-containing protein 1; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be involved in pre-mRNA splicing ; Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
    
   0.705
SGSM3
Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells.
    
   0.665
PRR36
Proline-rich protein 36; Proline rich 36.
      
 0.651
TMEM38A
Trimeric intracellular cation channel type A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
      
 0.629
SCFD1
Sec1 family domain-containing protein 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity).
    
 
 0.617
ODF3L2
Outer dense fiber of sperm tails 3 like 2.
      
 0.537
TM9SF3
Transmembrane 9 superfamily member 3.
   
  
 0.533
CASC4
Protein CASC4; Belongs to the GOLM1/CASC4 family.
   
  
 0.514
TMEM87A
Transmembrane protein 87A; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).
   
  
 0.495
VTI1A
Vesicle transport through interaction with t-SNAREs homolog 1A; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular [...]
   
  
 0.478
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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