Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SNTNSentan; May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules. (147 aa)    
Predicted Functional Partners:
C20orf85
Uncharacterized protein C20orf85; Chromosome 20 open reading frame 85.
   
  
 0.849
CAPSL
Calcyphosin-like protein; Calcyphosine like.
   
  
 0.752
FOXJ1
Forkhead box protein J1; Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). Activates the transcription of a variety of ciliary proteins in the developing brain and lung. Belongs to the FOXJ1 family.
   
  
 0.739
AKAP14
A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
   
    0.724
FAM216B
Protein FAM216B; Family with sequence similarity 216 member B; Belongs to the FAM216 family.
   
  
 0.722
LDLRAD1
Low density lipoprotein receptor class A domain containing 1.
   
  
 0.714
SAXO2
Stabilizer of axonemal microtubules 2.
   
  
 0.671
PIH1D3
Protein PIH1D3; Plays a role in cytoplasmic pre-assembly of axonemal dynein. Belongs to the PIH1 family.
   
  
 0.657
C5orf49
Uncharacterized protein C5orf49; Chromosome 5 open reading frame 49.
   
    0.634
PIFO
Protein pitchfork; During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle- dependent manner.
   
  
 0.616
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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