| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C16orf92 | DCST1 | ENSP00000300575 | ENSP00000295542 | Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92. | E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. | 0.663 |
| C16orf92 | DCST2 | ENSP00000300575 | ENSP00000357409 | Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92. | DC-STAMP domain containing 2. | 0.701 |
| C16orf92 | IZUMO1 | ENSP00000300575 | ENSP00000327786 | Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92. | Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand- receptor interaction probably does not act as a membrane 'fusogen'. | 0.676 |
| C16orf92 | IZUMO1R | ENSP00000300575 | ENSP00000332963 | Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92. | Sperm-egg fusion protein Juno; Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate. | 0.494 |
| C16orf92 | SPACA6 | ENSP00000300575 | ENSP00000490829 | Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92. | Sperm acrosome membrane-associated protein 6; Sperm protein potentially involved sperm-egg fusion. | 0.752 |
| C16orf92 | TMEM95 | ENSP00000300575 | ENSP00000374632 | Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92. | Transmembrane protein 95. | 0.776 |
| CD9 | DCST1 | ENSP00000371958 | ENSP00000295542 | CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents mac [...] | E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. | 0.505 |
| CD9 | DCST2 | ENSP00000371958 | ENSP00000357409 | CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents mac [...] | DC-STAMP domain containing 2. | 0.406 |
| CD9 | IZUMO1 | ENSP00000371958 | ENSP00000327786 | CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents mac [...] | Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand- receptor interaction probably does not act as a membrane 'fusogen'. | 0.807 |
| CD9 | SPACA6 | ENSP00000371958 | ENSP00000490829 | CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents mac [...] | Sperm acrosome membrane-associated protein 6; Sperm protein potentially involved sperm-egg fusion. | 0.627 |
| CD9 | TMEM95 | ENSP00000371958 | ENSP00000374632 | CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents mac [...] | Transmembrane protein 95. | 0.463 |
| DCST1 | C16orf92 | ENSP00000295542 | ENSP00000300575 | E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. | Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92. | 0.663 |
| DCST1 | CD9 | ENSP00000295542 | ENSP00000371958 | E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. | CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents mac [...] | 0.505 |
| DCST1 | DCST2 | ENSP00000295542 | ENSP00000357409 | E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. | DC-STAMP domain containing 2. | 0.577 |
| DCST1 | IZUMO1 | ENSP00000295542 | ENSP00000327786 | E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. | Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand- receptor interaction probably does not act as a membrane 'fusogen'. | 0.702 |
| DCST1 | IZUMO1R | ENSP00000295542 | ENSP00000332963 | E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. | Sperm-egg fusion protein Juno; Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate. | 0.445 |
| DCST1 | SPACA4 | ENSP00000295542 | ENSP00000312774 | E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. | Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. | 0.494 |
| DCST1 | SPACA6 | ENSP00000295542 | ENSP00000490829 | E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. | Sperm acrosome membrane-associated protein 6; Sperm protein potentially involved sperm-egg fusion. | 0.814 |
| DCST1 | TMEM95 | ENSP00000295542 | ENSP00000374632 | E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. | Transmembrane protein 95. | 0.831 |
| DCST2 | C16orf92 | ENSP00000357409 | ENSP00000300575 | DC-STAMP domain containing 2. | Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92. | 0.701 |