Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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SPATA1Spermatogenesis-associated protein 1; Spermatogenesis associated 1. (459 aa)    
Predicted Functional Partners:
TLK1
Serine/threonine-protein kinase tousled-like 1; Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. Belongs to the protein kinase superfamily. [...]
   
   0.966
TLK2
Serine/threonine-protein kinase tousled-like 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.
    
   0.903
NECAP1
Adaptin ear-binding coat-associated protein 1; Involved in endocytosis.
    
   0.651
SPATA6
Spermatogenesis-associated protein 6; Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits; Belongs to the SPATA6 family.
   
  
 0.597
SPATA6L
Spermatogenesis associated 6 like; Belongs to the SPATA6 family.
   
  
 0.569
SPATA17
Spermatogenesis-associated protein 17; Spermatogenesis associated 17.
   
  
 0.563
SPATA20
Spermatogenesis-associated protein 20; May play a role in fertility regulation.
      
 0.545
SPATA22
Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I.
   
  
 0.512
MAGEB16
Melanoma-associated antigen B16; MAGE family member B16.
      
 0.507
SPATA7
Spermatogenesis-associated protein 7; Involved in the maintenance of both rod and cone photoreceptor cells (By similarity). It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as photoreceptor-specific localization of proximal CC proteins at the distal CC (By similarity). Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration (By similarity).
      
 0.486
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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