Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SPINT4Serine peptidase inhibitor, Kunitz type 4. (99 aa)    
Predicted Functional Partners:
WFDC6
WAP four-disulfide core domain 6.
      
 0.812
WFDC8
WAP four-disulfide core domain 8.
   
  
 0.750
WFDC13
WAP four-disulfide core domain protein 13; Putative acid-stable proteinase inhibitor.
   
 
 0.721
WFDC10B
Protein WFDC10B; WAP four-disulfide core domain 10B.
   
  
 0.591
EPPIN
Eppin; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility.
      
 0.571
SEMG1
Seminal basic protein; Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.
      
 0.547
LCN9
Epididymal-specific lipocalin-9; Lipocalin 9.
   
  
 0.539
WFDC10A
WAP four-disulfide core domain 10A.
      
 0.529
SPINT3
Serine peptidase inhibitor, Kunitz type 3.
   
  
 0.514
SEMG2
Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
      
 0.491
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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