Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SPNS3Protein spinster homolog 3; Sphingolipid transporter. (512 aa)    
Predicted Functional Partners:
SLC22A1
Solute carrier family 22 member 1; Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1- methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1- methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N- methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA recepto [...]
    
 
 0.892
CLCC1
Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel. Plays a role in retina development. Belongs to the chloride channel MCLC family.
    
 
 0.833
MFSD10
Major facilitator superfamily domain-containing protein 10; Confers cellular resistance to apoptosis induced by the non- steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump; Belongs to the major facilitator superfamily.
   
  
 0.591
MFSD3
Major facilitator superfamily domain containing 3.
      
 0.568
SVOPL
Putative transporter SVOPL; SVOP like; Belongs to the major facilitator superfamily.
   
  
 0.555
MFSD9
Major facilitator superfamily domain containing 9.
   
  
 0.546
MFSD11
UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family.
      
 0.544
MFSD2B
Major facilitator superfamily domain-containing protein 2B; Cation-dependent lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets. Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (By similarity). Does not transport lysophosphatidylcholine (LPC) (By similarity). Belongs to the major facilitator superfamily.
      
 0.532
MFSD5
Molybdate-anion transporter; Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum; Belongs to the major facilitator superfamily.
      
 0.528
MFSD6L
Major facilitator superfamily domain containing 6 like.
   
  
 0.521
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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