| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASPHD2 | HPS4 | ENSP00000215906 | ENSP00000381213 | Aspartate beta-hydroxylase domain-containing protein 2; May function as 2-oxoglutarate-dependent dioxygenase. | Hermansky-Pudlak syndrome 4 protein; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38. | 0.521 |
| ASPHD2 | SRRD | ENSP00000215906 | ENSP00000215917 | Aspartate beta-hydroxylase domain-containing protein 2; May function as 2-oxoglutarate-dependent dioxygenase. | SRR1-like protein; Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. | 0.562 |
| COMMD9 | SRRD | ENSP00000263401 | ENSP00000215917 | COMM domain-containing protein 9; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride- sensitive sodium channel (ENaC) subunits. | SRR1-like protein; Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. | 0.452 |
| HDGFL3 | SNN | ENSP00000299633 | ENSP00000329287 | Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation. | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation. | 0.471 |
| HDGFL3 | SRRD | ENSP00000299633 | ENSP00000215917 | Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation. | SRR1-like protein; Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. | 0.504 |
| HMCN2 | SRRD | ENSP00000485357 | ENSP00000215917 | Hemicentin-2; Hemicentin 2. | SRR1-like protein; Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. | 0.489 |
| HPS4 | ASPHD2 | ENSP00000381213 | ENSP00000215906 | Hermansky-Pudlak syndrome 4 protein; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38. | Aspartate beta-hydroxylase domain-containing protein 2; May function as 2-oxoglutarate-dependent dioxygenase. | 0.521 |
| HPS4 | SRRD | ENSP00000381213 | ENSP00000215917 | Hermansky-Pudlak syndrome 4 protein; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38. | SRR1-like protein; Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. | 0.500 |
| RAB11FIP5 | SRRD | ENSP00000258098 | ENSP00000215917 | Rab11 family-interacting protein 5; Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. | SRR1-like protein; Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. | 0.451 |
| RRP8 | SRRD | ENSP00000254605 | ENSP00000215917 | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] | SRR1-like protein; Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. | 0.515 |
| SNN | HDGFL3 | ENSP00000329287 | ENSP00000299633 | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation. | Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation. | 0.471 |
| SNN | SRRD | ENSP00000329287 | ENSP00000215917 | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation. | SRR1-like protein; Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. | 0.532 |
| SRRD | ASPHD2 | ENSP00000215917 | ENSP00000215906 | SRR1-like protein; Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. | Aspartate beta-hydroxylase domain-containing protein 2; May function as 2-oxoglutarate-dependent dioxygenase. | 0.562 |
| SRRD | COMMD9 | ENSP00000215917 | ENSP00000263401 | SRR1-like protein; Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. | COMM domain-containing protein 9; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride- sensitive sodium channel (ENaC) subunits. | 0.452 |
| SRRD | HDGFL3 | ENSP00000215917 | ENSP00000299633 | SRR1-like protein; Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. | Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation. | 0.504 |
| SRRD | HMCN2 | ENSP00000215917 | ENSP00000485357 | SRR1-like protein; Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. | Hemicentin-2; Hemicentin 2. | 0.489 |
| SRRD | HPS4 | ENSP00000215917 | ENSP00000381213 | SRR1-like protein; Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. | Hermansky-Pudlak syndrome 4 protein; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38. | 0.500 |
| SRRD | RAB11FIP5 | ENSP00000215917 | ENSP00000258098 | SRR1-like protein; Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. | Rab11 family-interacting protein 5; Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. | 0.451 |
| SRRD | RRP8 | ENSP00000215917 | ENSP00000254605 | SRR1-like protein; Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] | 0.515 |
| SRRD | SNN | ENSP00000215917 | ENSP00000329287 | SRR1-like protein; Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation. | 0.532 |
