| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGFG1 | RAB5A | ENSP00000387282 | ENSP00000273047 | Arf-GAP domain and FG repeat-containing protein 1; Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | 0.901 |
| AGFG1 | TBC1D3 | ENSP00000387282 | ENSP00000478683 | Arf-GAP domain and FG repeat-containing protein 1; Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. | TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. | 0.552 |
| CUL7 | TBC1D3 | ENSP00000438788 | ENSP00000478683 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. | 0.573 |
| GGA3 | RAB5A | ENSP00000438085 | ENSP00000273047 | ADP-ribosylation factor-binding protein GGA3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels. Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS [...] | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | 0.671 |
| GGA3 | TBC1D3 | ENSP00000438085 | ENSP00000478683 | ADP-ribosylation factor-binding protein GGA3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels. Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS [...] | TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. | 0.756 |
| RAB5A | AGFG1 | ENSP00000273047 | ENSP00000387282 | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | Arf-GAP domain and FG repeat-containing protein 1; Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. | 0.901 |
| RAB5A | GGA3 | ENSP00000273047 | ENSP00000438085 | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | ADP-ribosylation factor-binding protein GGA3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels. Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS [...] | 0.671 |
| RAB5A | TBC1D3 | ENSP00000273047 | ENSP00000478683 | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. | 0.599 |
| TBC1D3 | AGFG1 | ENSP00000478683 | ENSP00000387282 | TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. | Arf-GAP domain and FG repeat-containing protein 1; Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. | 0.552 |
| TBC1D3 | CUL7 | ENSP00000478683 | ENSP00000438788 | TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | 0.573 |
| TBC1D3 | GGA3 | ENSP00000478683 | ENSP00000438085 | TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. | ADP-ribosylation factor-binding protein GGA3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels. Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS [...] | 0.756 |
| TBC1D3 | RAB5A | ENSP00000478683 | ENSP00000273047 | TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | 0.599 |
| TBC1D3 | TBC1D3E | ENSP00000478683 | ENSP00000483965 | TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. | TBC1 domain family member 3E; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). | 0.978 |
| TBC1D3 | TBC1D3F | ENSP00000478683 | ENSP00000477679 | TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. | TBC1 domain family member 3F. | 0.779 |
| TBC1D3 | TBC1D3H | ENSP00000478683 | ENSP00000482630 | TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. | TBC1 domain family member 3H; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). | 0.978 |
| TBC1D3 | TBC1D3K | ENSP00000478683 | ENSP00000484181 | TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. | TBC1 domain family member 3K; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). | 0.978 |
| TBC1D3 | TBC1D3L | ENSP00000478683 | ENSP00000481508 | TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. | TBC1 domain family member 3L; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). | 0.636 |
| TBC1D3 | USP32 | ENSP00000478683 | ENSP00000300896 | TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family. | 0.912 |
| TBC1D3E | TBC1D3 | ENSP00000483965 | ENSP00000478683 | TBC1 domain family member 3E; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). | TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. | 0.978 |
| TBC1D3E | TBC1D3H | ENSP00000483965 | ENSP00000482630 | TBC1 domain family member 3E; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). | TBC1 domain family member 3H; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). | 0.978 |
