| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDC42 | COG1 | ENSP00000497733 | ENSP00000299886 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | 0.936 |
| CDC42 | COG2 | ENSP00000497733 | ENSP00000355629 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | 0.902 |
| CDC42 | COG3 | ENSP00000497733 | ENSP00000258654 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | 0.905 |
| CDC42 | COG4 | ENSP00000497733 | ENSP00000315775 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Belongs to the COG4 family. | 0.948 |
| CDC42 | COG5 | ENSP00000497733 | ENSP00000297135 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | Conserved oligomeric Golgi complex subunit 5; Required for normal Golgi function; Belongs to the COG5 family. | 0.969 |
| CDC42 | COG6 | ENSP00000497733 | ENSP00000397441 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | 0.911 |
| CDC42 | COG7 | ENSP00000497733 | ENSP00000305442 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function. | 0.906 |
| CDC42 | COG8 | ENSP00000497733 | ENSP00000497669 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.903 |
| CDC42 | TMEM115 | ENSP00000497733 | ENSP00000266025 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | Transmembrane protein 115; May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. | 0.900 |
| COG1 | CDC42 | ENSP00000299886 | ENSP00000497733 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | 0.936 |
| COG1 | COG2 | ENSP00000299886 | ENSP00000355629 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | 0.999 |
| COG1 | COG3 | ENSP00000299886 | ENSP00000258654 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | 0.999 |
| COG1 | COG4 | ENSP00000299886 | ENSP00000315775 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Belongs to the COG4 family. | 0.999 |
| COG1 | COG5 | ENSP00000299886 | ENSP00000297135 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 5; Required for normal Golgi function; Belongs to the COG5 family. | 0.999 |
| COG1 | COG6 | ENSP00000299886 | ENSP00000397441 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | 0.999 |
| COG1 | COG7 | ENSP00000299886 | ENSP00000305442 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function. | 0.999 |
| COG1 | COG8 | ENSP00000299886 | ENSP00000497669 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.999 |
| COG1 | TMEM115 | ENSP00000299886 | ENSP00000266025 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Transmembrane protein 115; May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. | 0.927 |
| COG2 | CDC42 | ENSP00000355629 | ENSP00000497733 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | 0.902 |
| COG2 | COG1 | ENSP00000355629 | ENSP00000299886 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | 0.999 |
