Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-expression
Experiments
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[Homology]
Score
TMEM212Transmembrane protein 212. (194 aa)    
Predicted Functional Partners:
CFAP54
Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella.
   
  
 0.954
WDPCP
WD repeat-containing and planar cell polarity effector protein fritz homolog; Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).
   
    0.730
MAB21L3
Protein mab-21-like 3; Mab-21 like 3.
   
  
 0.632
FAM216B
Protein FAM216B; Family with sequence similarity 216 member B; Belongs to the FAM216 family.
   
  
 0.561
DYNLRB2
Dynein light chain roadblock-type 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
   
 
 0.559
TMEM221
Transmembrane protein 221.
      
 0.514
SNTN
Sentan; May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules.
   
  
 0.506
ADAMTSL3
ADAMTS-like protein 3; ADAMTS like 3.
   
    0.502
TMEM171
Transmembrane protein 171.
      
 0.500
LDLRAD1
Low density lipoprotein receptor class A domain containing 1.
  
  
 0.475
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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