TMEM50A protein (human) - STRING interaction network

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Score

TMEM50A

Transmembrane protein 50A; Belongs to the UPF0220 family. (157 aa)

Predicted Functional Partners:

RHCE

0.950

LEPROT

0.944

LEPROTL1

0.893

VPS4B

0.715

VPS4A

0.715

CHMP3

0.713

RNF103-CHMP3

0.713

MACO1

0.648

RSRP1

0.606

TMEM60

0.562

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHMP3	RNF103-CHMP3	ENSP00000263856	ENSP00000474823	Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...]	RNF103-CHMP3 readthrough.	0.992
CHMP3	TMEM50A	ENSP00000263856	ENSP00000363478	Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...]	Transmembrane protein 50A; Belongs to the UPF0220 family.	0.713
CHMP3	VPS4A	ENSP00000263856	ENSP00000254950	Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...]	Vacuolar protein sorting-associated protein 4A; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth fact [...]	0.999
CHMP3	VPS4B	ENSP00000263856	ENSP00000238497	Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...]	Vacuolar protein sorting-associated protein 4B; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth fact [...]	0.981
LEPROT	TMEM50A	ENSP00000483521	ENSP00000363478	Leptin receptor gene-related protein; Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.	Transmembrane protein 50A; Belongs to the UPF0220 family.	0.944
LEPROTL1	TMEM50A	ENSP00000428281	ENSP00000363478	Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family.	Transmembrane protein 50A; Belongs to the UPF0220 family.	0.893
MACO1	RHCE	ENSP00000363463	ENSP00000294413	Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family.	Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.	0.604
MACO1	RSRP1	ENSP00000363463	ENSP00000243189	Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family.	Arginine and serine rich protein 1.	0.613
MACO1	TMEM50A	ENSP00000363463	ENSP00000363478	Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family.	Transmembrane protein 50A; Belongs to the UPF0220 family.	0.648
RHCE	MACO1	ENSP00000294413	ENSP00000363463	Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.	Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family.	0.604
RHCE	RSRP1	ENSP00000294413	ENSP00000243189	Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.	Arginine and serine rich protein 1.	0.534
RHCE	TMEM50A	ENSP00000294413	ENSP00000363478	Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.	Transmembrane protein 50A; Belongs to the UPF0220 family.	0.950
RNF103-CHMP3	CHMP3	ENSP00000474823	ENSP00000263856	RNF103-CHMP3 readthrough.	Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...]	0.992
RNF103-CHMP3	TMEM50A	ENSP00000474823	ENSP00000363478	RNF103-CHMP3 readthrough.	Transmembrane protein 50A; Belongs to the UPF0220 family.	0.713
RNF103-CHMP3	VPS4A	ENSP00000474823	ENSP00000254950	RNF103-CHMP3 readthrough.	Vacuolar protein sorting-associated protein 4A; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth fact [...]	0.995
RNF103-CHMP3	VPS4B	ENSP00000474823	ENSP00000238497	RNF103-CHMP3 readthrough.	Vacuolar protein sorting-associated protein 4B; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth fact [...]	0.965
RSRP1	MACO1	ENSP00000243189	ENSP00000363463	Arginine and serine rich protein 1.	Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family.	0.613
RSRP1	RHCE	ENSP00000243189	ENSP00000294413	Arginine and serine rich protein 1.	Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.	0.534
RSRP1	TMEM50A	ENSP00000243189	ENSP00000363478	Arginine and serine rich protein 1.	Transmembrane protein 50A; Belongs to the UPF0220 family.	0.606
TMEM50A	CHMP3	ENSP00000363478	ENSP00000263856	Transmembrane protein 50A; Belongs to the UPF0220 family.	Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...]	0.713