TMEM95 protein (human) - STRING interaction network

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[Homology]

Score

TMEM95

Transmembrane protein 95. (203 aa)

Predicted Functional Partners:

SPACA6

0.921

DCST2

0.840

IZUMO1

0.835

DCST1

0.831

C16orf92

0.776

CCDC189

0.630

IZUMO1R

0.627

ARMC3

0.599

IZUMO2

0.596

SPEM1

0.571

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARMC3	CCDC189	ENSP00000298032	ENSP00000437532	Armadillo repeat containing 3.	Coiled-coil domain containing 189.	0.609
ARMC3	TMEM95	ENSP00000298032	ENSP00000374632	Armadillo repeat containing 3.	Transmembrane protein 95.	0.599
C16orf92	DCST1	ENSP00000300575	ENSP00000295542	Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92.	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.	0.663
C16orf92	DCST2	ENSP00000300575	ENSP00000357409	Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92.	DC-STAMP domain containing 2.	0.701
C16orf92	IZUMO1	ENSP00000300575	ENSP00000327786	Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92.	Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand- receptor interaction probably does not act as a membrane 'fusogen'.	0.676
C16orf92	IZUMO1R	ENSP00000300575	ENSP00000332963	Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92.	Sperm-egg fusion protein Juno; Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.	0.494
C16orf92	SPACA6	ENSP00000300575	ENSP00000490829	Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92.	Sperm acrosome membrane-associated protein 6; Sperm protein potentially involved sperm-egg fusion.	0.752
C16orf92	TMEM95	ENSP00000300575	ENSP00000374632	Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92.	Transmembrane protein 95.	0.776
CCDC189	ARMC3	ENSP00000437532	ENSP00000298032	Coiled-coil domain containing 189.	Armadillo repeat containing 3.	0.609
CCDC189	TMEM95	ENSP00000437532	ENSP00000374632	Coiled-coil domain containing 189.	Transmembrane protein 95.	0.630
DCST1	C16orf92	ENSP00000295542	ENSP00000300575	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.	Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92.	0.663
DCST1	DCST2	ENSP00000295542	ENSP00000357409	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.	DC-STAMP domain containing 2.	0.577
DCST1	IZUMO1	ENSP00000295542	ENSP00000327786	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.	Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand- receptor interaction probably does not act as a membrane 'fusogen'.	0.702
DCST1	IZUMO1R	ENSP00000295542	ENSP00000332963	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.	Sperm-egg fusion protein Juno; Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.	0.445
DCST1	SPACA6	ENSP00000295542	ENSP00000490829	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.	Sperm acrosome membrane-associated protein 6; Sperm protein potentially involved sperm-egg fusion.	0.814
DCST1	TMEM95	ENSP00000295542	ENSP00000374632	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.	Transmembrane protein 95.	0.831
DCST2	C16orf92	ENSP00000357409	ENSP00000300575	DC-STAMP domain containing 2.	Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92.	0.701
DCST2	DCST1	ENSP00000357409	ENSP00000295542	DC-STAMP domain containing 2.	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.	0.577
DCST2	IZUMO1	ENSP00000357409	ENSP00000327786	DC-STAMP domain containing 2.	Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand- receptor interaction probably does not act as a membrane 'fusogen'.	0.737
DCST2	IZUMO1R	ENSP00000357409	ENSP00000332963	DC-STAMP domain containing 2.	Sperm-egg fusion protein Juno; Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.	0.478