| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACTG1 | TSGA10 | ENSP00000458162 | ENSP00000377123 | Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Testis-specific gene 10 protein; Plays a role in spermatogenesis. When overexpressed, prevents nuclear localization of HIF1A (By similarity). Belongs to the CEP135/TSGA10 family. | 0.525 |
| BRDT | CEP112 | ENSP00000387822 | ENSP00000376522 | Bromodomain testis-specific protein; Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also re [...] | Centrosomal protein 112. | 0.498 |
| BRDT | PMFBP1 | ENSP00000387822 | ENSP00000237353 | Bromodomain testis-specific protein; Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also re [...] | Polyamine-modulated factor 1-binding protein 1; Required for normal spermatogenesis. It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity. May also be involved in the general organization of cellular cytoskeleton (By similarity). | 0.632 |
| BRDT | SUN5 | ENSP00000387822 | ENSP00000348496 | Bromodomain testis-specific protein; Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also re [...] | SUN domain-containing protein 5; Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. | 0.601 |
| BRDT | TSGA10 | ENSP00000387822 | ENSP00000377123 | Bromodomain testis-specific protein; Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also re [...] | Testis-specific gene 10 protein; Plays a role in spermatogenesis. When overexpressed, prevents nuclear localization of HIF1A (By similarity). Belongs to the CEP135/TSGA10 family. | 0.585 |
| CEP112 | BRDT | ENSP00000376522 | ENSP00000387822 | Centrosomal protein 112. | Bromodomain testis-specific protein; Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also re [...] | 0.498 |
| CEP112 | DNAH6 | ENSP00000376522 | ENSP00000374045 | Centrosomal protein 112. | Dynein heavy chain 6, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity); Belongs to the dynein heavy chain family. | 0.519 |
| CEP112 | PMFBP1 | ENSP00000376522 | ENSP00000237353 | Centrosomal protein 112. | Polyamine-modulated factor 1-binding protein 1; Required for normal spermatogenesis. It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity. May also be involved in the general organization of cellular cytoskeleton (By similarity). | 0.696 |
| CEP112 | SPATA6 | ENSP00000376522 | ENSP00000360913 | Centrosomal protein 112. | Spermatogenesis-associated protein 6; Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits; Belongs to the SPATA6 family. | 0.405 |
| CEP112 | SPATC1L | ENSP00000376522 | ENSP00000291672 | Centrosomal protein 112. | Speriolin-like protein; Spermatogenesis and centriole associated 1 like. | 0.503 |
| CEP112 | SUN5 | ENSP00000376522 | ENSP00000348496 | Centrosomal protein 112. | SUN domain-containing protein 5; Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. | 0.591 |
| CEP112 | TSGA10 | ENSP00000376522 | ENSP00000377123 | Centrosomal protein 112. | Testis-specific gene 10 protein; Plays a role in spermatogenesis. When overexpressed, prevents nuclear localization of HIF1A (By similarity). Belongs to the CEP135/TSGA10 family. | 0.670 |
| DNAH6 | CEP112 | ENSP00000374045 | ENSP00000376522 | Dynein heavy chain 6, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity); Belongs to the dynein heavy chain family. | Centrosomal protein 112. | 0.519 |
| DNAH6 | PMFBP1 | ENSP00000374045 | ENSP00000237353 | Dynein heavy chain 6, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity); Belongs to the dynein heavy chain family. | Polyamine-modulated factor 1-binding protein 1; Required for normal spermatogenesis. It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity. May also be involved in the general organization of cellular cytoskeleton (By similarity). | 0.600 |
| DNAH6 | SPAG6 | ENSP00000374045 | ENSP00000365811 | Dynein heavy chain 6, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity); Belongs to the dynein heavy chain family. | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. | 0.560 |
| DNAH6 | SUN5 | ENSP00000374045 | ENSP00000348496 | Dynein heavy chain 6, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity); Belongs to the dynein heavy chain family. | SUN domain-containing protein 5; Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. | 0.703 |
| DNAH6 | TSGA10 | ENSP00000374045 | ENSP00000377123 | Dynein heavy chain 6, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity); Belongs to the dynein heavy chain family. | Testis-specific gene 10 protein; Plays a role in spermatogenesis. When overexpressed, prevents nuclear localization of HIF1A (By similarity). Belongs to the CEP135/TSGA10 family. | 0.520 |
| HOOK1 | PMFBP1 | ENSP00000360252 | ENSP00000237353 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). | Polyamine-modulated factor 1-binding protein 1; Required for normal spermatogenesis. It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity. May also be involved in the general organization of cellular cytoskeleton (By similarity). | 0.586 |
| HOOK1 | SPATA6 | ENSP00000360252 | ENSP00000360913 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). | Spermatogenesis-associated protein 6; Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits; Belongs to the SPATA6 family. | 0.481 |
| HOOK1 | SUN5 | ENSP00000360252 | ENSP00000348496 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). | SUN domain-containing protein 5; Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. | 0.708 |
