TSPYL4 protein (human) - STRING interaction network

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Score

TSPYL4

Testis-specific Y-encoded-like protein 4; TSPY like 4. (414 aa)

Predicted Functional Partners:

MAGEA4

0.919

NAP1L5

0.867

CDK5RAP3

0.781

NAP1L3

0.677

TSPYL1

0.654

DFFA

0.644

NINL

0.576

KLHDC3

0.563

DEXI

0.526

NT5DC1

0.499

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK5RAP3	TSPYL4	ENSP00000438886	ENSP00000410943	CDK5 regulatory subunit-associated protein 3; Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May play a role in the unfold [...]	Testis-specific Y-encoded-like protein 4; TSPY like 4.	0.781
DEXI	TSPYL4	ENSP00000493467	ENSP00000410943	Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.	Testis-specific Y-encoded-like protein 4; TSPY like 4.	0.526
DFFA	TSPYL4	ENSP00000366237	ENSP00000410943	DNA fragmentation factor subunit alpha; Inhibitor of the caspase-activated DNase (DFF40).	Testis-specific Y-encoded-like protein 4; TSPY like 4.	0.644
KLHDC3	TSPYL4	ENSP00000313995	ENSP00000410943	Kelch domain-containing protein 3; May be involved in meiotic recombination process.	Testis-specific Y-encoded-like protein 4; TSPY like 4.	0.563
MAGEA4	TSPYL1	ENSP00000353379	ENSP00000357597	Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.	Testis-specific Y-encoded-like protein 1; TSPY like 1.	0.861
MAGEA4	TSPYL4	ENSP00000353379	ENSP00000410943	Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.	Testis-specific Y-encoded-like protein 4; TSPY like 4.	0.919
NAP1L3	TSPYL1	ENSP00000362171	ENSP00000357597	Nucleosome assembly protein 1 like 3.	Testis-specific Y-encoded-like protein 1; TSPY like 1.	0.618
NAP1L3	TSPYL4	ENSP00000362171	ENSP00000410943	Nucleosome assembly protein 1 like 3.	Testis-specific Y-encoded-like protein 4; TSPY like 4.	0.677
NAP1L5	TSPYL4	ENSP00000320488	ENSP00000410943	Nucleosome assembly protein 1 like 5.	Testis-specific Y-encoded-like protein 4; TSPY like 4.	0.867
NINL	TSPYL4	ENSP00000278886	ENSP00000410943	Ninein-like protein; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis.	Testis-specific Y-encoded-like protein 4; TSPY like 4.	0.576
NT5DC1	TSPYL4	ENSP00000326858	ENSP00000410943	5'-nucleotidase domain containing 1.	Testis-specific Y-encoded-like protein 4; TSPY like 4.	0.499
TSPYL1	MAGEA4	ENSP00000357597	ENSP00000353379	Testis-specific Y-encoded-like protein 1; TSPY like 1.	Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.	0.861
TSPYL1	NAP1L3	ENSP00000357597	ENSP00000362171	Testis-specific Y-encoded-like protein 1; TSPY like 1.	Nucleosome assembly protein 1 like 3.	0.618
TSPYL1	TSPYL4	ENSP00000357597	ENSP00000410943	Testis-specific Y-encoded-like protein 1; TSPY like 1.	Testis-specific Y-encoded-like protein 4; TSPY like 4.	0.654
TSPYL4	CDK5RAP3	ENSP00000410943	ENSP00000438886	Testis-specific Y-encoded-like protein 4; TSPY like 4.	CDK5 regulatory subunit-associated protein 3; Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May play a role in the unfold [...]	0.781
TSPYL4	DEXI	ENSP00000410943	ENSP00000493467	Testis-specific Y-encoded-like protein 4; TSPY like 4.	Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.	0.526
TSPYL4	DFFA	ENSP00000410943	ENSP00000366237	Testis-specific Y-encoded-like protein 4; TSPY like 4.	DNA fragmentation factor subunit alpha; Inhibitor of the caspase-activated DNase (DFF40).	0.644
TSPYL4	KLHDC3	ENSP00000410943	ENSP00000313995	Testis-specific Y-encoded-like protein 4; TSPY like 4.	Kelch domain-containing protein 3; May be involved in meiotic recombination process.	0.563
TSPYL4	MAGEA4	ENSP00000410943	ENSP00000353379	Testis-specific Y-encoded-like protein 4; TSPY like 4.	Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.	0.919
TSPYL4	NAP1L3	ENSP00000410943	ENSP00000362171	Testis-specific Y-encoded-like protein 4; TSPY like 4.	Nucleosome assembly protein 1 like 3.	0.677