Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TTC23Tetratricopeptide repeat protein 23; Participates positively in the ciliary Hedgehog (Hh) signaling. (447 aa)    
Predicted Functional Partners:
TRIM10
Tripartite motif-containing protein 10; Seems to play an important role in erythropoiesis. Belongs to the TRIM/RBCC family.
    
   0.804
IQCE
IQ domain-containing protein E; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (By similarity). Required for proper limb morphogenesis.
   
 
 0.671
FAM92A
Protein FAM92A; Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Probable regulator of ciliogenesis involved in limb morphogenesis. In cooperation with CBY1 it is involved in the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis; Belongs to the FAM92 family.
   
  
 0.609
EFCAB7
EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia.
   
 
 0.605
TXNDC15
Thioredoxin domain-containing protein 15; Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Involved in ciliogenesis.
   
  
 0.565
PGPEP1L
Pyroglutamyl-peptidase 1-like protein; Pyroglutamyl-peptidase I like.
      
 0.549
CZIB
CXXC motif containing zinc binding protein; Belongs to the UPF0587 family.
   
  
 0.482
SNAPC1
snRNA-activating protein complex subunit 1; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
      
 0.466
RAP1GDS1
Rap1 GTPase-GDP dissociation stimulator 1; Stimulates GDP/GTP exchange reaction of a group of small GTP- binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein.
      
 0.456
TTC24
Tetratricopeptide repeat domain 24.
      
 0.455
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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