Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
TTC9BTetratricopeptide repeat domain 9B; Belongs to the TTC9 family. (239 aa)    
Predicted Functional Partners:
MICU3
Calcium uptake protein 3, mitochondrial; May play a role in mitochondrial calcium uptake.
    
   0.830
HP1BP3
Heterochromatin protein 1-binding protein 3; Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo- resistance and self-renewal.
   
 
 0.775
DMAC2
Distal membrane-arm assembly complex protein 2; Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. Belongs to the ATP synthase subunit s family.
      
 0.593
IRGQ
Immunity-related GTPase family Q protein; Immunity related GTPase Q; Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
   
  
 0.540
TULP2
TUB like protein 2; Belongs to the TUB family.
   
  
 0.524
HIPK4
Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
   
  
 0.514
LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3; Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity).
   
 
 0.513
SBK1
Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
   
  
 0.490
ABRACL
Costars family protein ABRACL; ABRA C-terminal like; Belongs to the costars family.
      
 0.485
ERICH1
Glutamate-rich protein 1; Glutamate rich 1.
      
 0.477
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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