Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TVP23BTrans-golgi network vesicle protein 23 homolog B; Belongs to the TVP23 family. (205 aa)    
Predicted Functional Partners:
YIPF2
Protein YIPF2; Yip1 domain family member 2.
   
 
 0.881
YIPF1
Protein YIPF1; Yip1 domain family member 1; Belongs to the YIP1 family.
   
 
 0.880
TVP23C
Trans-golgi network vesicle protein 23 homolog C; Belongs to the TVP23 family.
  
   
0.783
WLS
Protein wntless homolog; Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
    
   0.761
YIPF6
Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression.
   
 
 0.671
YIPF4
Protein YIPF4; Involved in the maintenance of the Golgi structure. Belongs to the YIP1 family.
   
 
 0.637
CDRT15
CMT1A duplicated region transcript 15.
      
 0.571
CDRT4
CMT1A duplicated region transcript 4.
 
    
 0.550
ATP6V0A1
V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).
    
 
 0.464
DDX39A
ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily.
    
   0.457
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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