Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
WFDC3WAP four-disulfide core domain 3. (231 aa)    
Predicted Functional Partners:
WFDC10B
Protein WFDC10B; WAP four-disulfide core domain 10B.
   
  
 0.716
WFDC13
WAP four-disulfide core domain protein 13; Putative acid-stable proteinase inhibitor.
   
 
 0.589
DUX4
Double homeobox protein 4-like protein 2; May be involved in transcriptional regulation.
      
 0.570
WFDC2
WAP four-disulfide core domain protein 2; Broad range protease inhibitor.
  
  
 0.565
SPATA25
Spermatogenesis-associated protein 25; May play a role in spermatogenesis. Belongs to the SPATA25 family.
   
  
 0.540
TRIM36
E3 ubiquitin-protein ligase TRIM36; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization. Belongs to the TRIM/RBCC family.
      
 0.535
ZSWIM1
Zinc finger SWIM-type containing 1.
   
  
 0.523
DNTTIP1
Deoxynucleotidyltransferase terminal-interacting protein 1; Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.
   
  
 0.522
WFDC10A
WAP four-disulfide core domain 10A.
      
 0.518
CSN2
Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family.
   
  
 0.508
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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