Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
WFDC9Protein WFDC9; WAP four-disulfide core domain 9. (89 aa)    
Predicted Functional Partners:
WFDC8
WAP four-disulfide core domain 8.
   
  
 0.755
WFDC13
WAP four-disulfide core domain protein 13; Putative acid-stable proteinase inhibitor.
   
  
 0.703
SPACA4
Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization.
   
    0.699
WFDC10A
WAP four-disulfide core domain 10A.
   
  
 0.624
SPINT3
Serine peptidase inhibitor, Kunitz type 3.
   
  
 0.591
PATE1
Prostate and testis expressed 1; Belongs to the PATE family.
   
    0.568
CTSC
Dipeptidyl peptidase 1 exclusion domain chain; Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII; Belongs to the peptidase C1 family.
    
   0.560
DEFB119
Defensin beta 119.
   
  
 0.545
DEFB129
Beta-defensin 129; Has antibacterial activity.
   
  
 0.542
EDDM3A
Epididymal secretory protein E3-alpha; Possible function in sperm maturation.
   
  
 0.527
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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