Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
XAGE1AX antigen family member 1A. (81 aa)    
Predicted Functional Partners:
XAGE1B
X antigen family member 1B.
   
  
0.978
XAGE3
X antigen family member 3.
      
 0.946
XAGE2
X antigen family member 2.
      
 0.919
CTAG1B
Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family.
   
  
 0.667
YAF2
YY1-associated factor 2; Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.
    
   0.611
MAGEA1
Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
   
  
 0.593
GAGE2A
G antigen 2A.
   
  
 0.593
CT45A1
Cancer/testis antigen family 45 member A1.
   
  
 0.590
MAGEC1
Melanoma-associated antigen C1; MAGE family member C1.
   
  
 0.564
GAGE1
G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family.
   
  
 0.564
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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